Novel oxidative functionalizations using earth-abundant transition metals

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The development of selective aerobic oxidations is fundamentally important to the chemical industry due to the abundance of molecular oxygen and the sustainable source of energy provided by its reduction to water. A particularly important group of oxidation reactions is the direct, one-step transfer of an oxygen or nitrogen atom to an inactivated organic substrate, which generates molecules that are typically used as fuels, solvents and lubricants or as building blocks in the synthesis of fine chemicals and pharmaceuticals. Also, these direct atom transfers avoid the intermediacy of wasteful protecting-group strategies. However, most current methods employ toxic metal ions or wasteful oxidants, which is undesired for scaled-up applications.