Development of New Carbene Catalysts and Design of Organocatalytic Reactions

新型卡宾催化剂的开发及有机催化反应的设计

• 批准号: RGPIN-2017-06230
• 负责人: Gravel, Michel
• 金额: $ 3.28万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632783
• 关键词: Development; New; Carbene; Catalysts; Design

Due to their unique properties, N-heterocyclic carbenes (NHCs) have attracted a lot of attention from the synthetic community. In addition to their widespread use as ligands for transition metals, they have been shown to act as catalysts in their own right. A remarkable feature of NHC catalysts is their ability to effect a reversal of reactivity (umpolung) for aldehydes. Whereas aldehydes normally react as electrophiles, they can behave as acyl anion equivalents in the presence of NHCs.

由于其独特的性质，N-杂环卡宾（NHC）引起了合成界的广泛关注。除了它们作为过渡金属的配体的广泛用途之外，它们已经被证明以其自身的权利作为催化剂。NHC催化剂的一个显著特征是它们能够实现醛的反应性逆转（upolung）。而醛通常作为亲电试剂反应，它们在NHC存在下可以表现为酰基阴离子等价物。