Development of New Carbene Catalysts and Design of Organocatalytic Reactions

新型卡宾催化剂的开发及有机催化反应的设计

基本信息

  • 批准号:
    RGPIN-2017-06230
  • 负责人:
  • 金额:
    $ 3.28万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2017
  • 资助国家:
    加拿大
  • 起止时间:
    2017-01-01 至 2018-12-31
  • 项目状态:
    已结题

项目摘要

Due to their unique properties, N-heterocyclic carbenes (NHCs) have attracted a lot of attention from the synthetic community. In addition to their widespread use as ligands for transition metals, they have been shown to act as catalysts in their own right. A remarkable feature of NHC catalysts is their ability to effect a reversal of reactivity (umpolung) for aldehydes. Whereas aldehydes normally react as electrophiles, they can behave as acyl anion equivalents in the presence of NHCs.
由于其独特的性质,N-杂环卡宾(NHC)引起了合成界的广泛关注。除了它们作为过渡金属的配体的广泛用途之外,它们已经被证明以其自身的权利作为催化剂。NHC催化剂的一个显著特征是它们能够实现醛的反应性逆转(upolung)。而醛通常作为亲电试剂反应,它们在NHC存在下可以表现为酰基阴离子等价物。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
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Gravel, Michel其他文献

Molecular and Cellular Mechanisms Underlying Neural Tube Defects in the Loop-tail Mutant Mouse
  • DOI:
    10.1021/bi902180m
  • 发表时间:
    2010-04-27
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Gravel, Michel;Iliescu, Alexandra;Gros, Philippe
  • 通讯作者:
    Gros, Philippe
Practical Synthesis and Highly Diastereoselective Diels-Alder Reactions of 1-Alkylthio-3-silyloxybutadienes
  • DOI:
    10.1021/jo901347u
  • 发表时间:
    2009-08-21
  • 期刊:
  • 影响因子:
    3.6
  • 作者:
    Holmes, Janice M.;Albert, Andrea L.;Gravel, Michel
  • 通讯作者:
    Gravel, Michel
Origin of Chemoselectivity in N-Heterocyclic Carbene Catalyzed Cross-Benzoin Reactions: DFT and Experimental Insights
  • DOI:
    10.1021/acs.joc.5b00301
  • 发表时间:
    2015-04-03
  • 期刊:
  • 影响因子:
    3.6
  • 作者:
    Langdon, Steven M.;Legault, Claude Y.;Gravel, Michel
  • 通讯作者:
    Gravel, Michel
Transmembrane Topology of Mammalian Planar Cell Polarity Protein Vangl1
  • DOI:
    10.1021/bi101767a
  • 发表时间:
    2011-03-29
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Iliescu, Alexandra;Gravel, Michel;Gros, Philippe
  • 通讯作者:
    Gros, Philippe
Loss of Membrane Targeting of Vangl Proteins Causes Neural Tube Defects
  • DOI:
    10.1021/bi101286d
  • 发表时间:
    2011-02-08
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Iliescu, Alexandra;Gravel, Michel;Gros, Philippe
  • 通讯作者:
    Gros, Philippe

Gravel, Michel的其他文献

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{{ truncateString('Gravel, Michel', 18)}}的其他基金

Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    RGPIN-2017-06230
  • 财政年份:
    2021
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    RGPIN-2017-06230
  • 财政年份:
    2020
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    RGPIN-2017-06230
  • 财政年份:
    2019
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    507840-2017
  • 财政年份:
    2019
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    RGPIN-2017-06230
  • 财政年份:
    2018
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    507840-2017
  • 财政年份:
    2018
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    507840-2017
  • 财政年份:
    2017
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Design of new reactions using N-Heterocyclic carbenes as organocatalysts
N-杂环卡宾作为有机催化剂的新反应设计
  • 批准号:
    341683-2010
  • 财政年份:
    2016
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Design of new reactions using N-Heterocyclic carbenes as organocatalysts
N-杂环卡宾作为有机催化剂的新反应设计
  • 批准号:
    341683-2010
  • 财政年份:
    2015
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Design of new reactions using N-Heterocyclic carbenes as organocatalysts
N-杂环卡宾作为有机催化剂的新反应设计
  • 批准号:
    341683-2010
  • 财政年份:
    2014
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual

相似海外基金

Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    RGPIN-2017-06230
  • 财政年份:
    2021
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    RGPIN-2017-06230
  • 财政年份:
    2020
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    RGPIN-2017-06230
  • 财政年份:
    2019
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    507840-2017
  • 财政年份:
    2019
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Development of new reactivity of novel metal-alkylidene and -carbene compllexes
新型金属亚烷基和卡宾配合物的新反应性的开发
  • 批准号:
    18H03911
  • 财政年份:
    2018
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    RGPIN-2017-06230
  • 财政年份:
    2018
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Individual
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    507840-2017
  • 财政年份:
    2018
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Development of New Carbene Catalysts and Design of Organocatalytic Reactions
新型卡宾催化剂的开发及有机催化反应的设计
  • 批准号:
    507840-2017
  • 财政年份:
    2017
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Discovery Grants Program - Accelerator Supplements
Syntheses of Novel Transition Metal-Carbene Complexes Effective for C-H Bond Activation of Alkanes and Development of New Synthetic Reactions
有效活化烷烃C-H键的新型过渡金属-卡宾配合物的合成及新合成反应的发展
  • 批准号:
    24750086
  • 财政年份:
    2012
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Development of new synthetic methodologies based on photochemical carbene formation reaction
基于光化学卡宾形成反应的新合成方法的开发
  • 批准号:
    23350016
  • 财政年份:
    2011
  • 资助金额:
    $ 3.28万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
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