Modified Nucleic Acid Structures to Interrogate Biochemical Processes and Design Principles of Responsive Nanodevices

修饰核酸结构以探究响应性纳米器件的生化过程和设计原理

• 批准号: RGPIN-2017-06683
• 负责人: Wilds, Christopher
• 金额: $ 3.28万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632860
• 关键词: Modified; Nucleic; Acid; Structures; Interrogate

Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are the central molecules of life. The discovery of the double helix structure of DNA, described by Watson and Crick over 60 years ago, continues to lead to numerous advances in biology and medicine. More recently, this elegant structure and the nature of its specific interactions have inspired scientists and engineers to investigate technological applications for nucleic acids. Through organic synthesis, modification of the nucleic acid scaffold can be achieved leading to molecules with increased functionality for a broad range of applications that can improve our society.

脱氧核糖核酸(DNA)和核糖核酸(RNA)是生命的中心分子。60多年前，沃森和克里克描述了DNA双螺旋结构的发现，这一发现继续推动着生物学和医学的许多进步。最近，这种优雅的结构及其特定相互作用的性质启发了科学家和工程师研究核酸的技术应用。通过有机合成，可以实现对核酸支架的修饰，从而获得具有更多官能度的分子，用于广泛的应用，从而改善我们的社会。