Development of akinetic swept-source OCT for middle ear imaging

光学相干层析成像(OCT)是一种新兴的光学成像手段，可以产生组织的深度分辨图像。OCT在视网膜和皮肤的小体积成像应用中得到了很好的应用。我的研究重点是将其用于成像更大的中耳体积。我的建议旨在开发中耳体积的快速实时2D成像技术，即多普勒OCT，以实现中耳对声音的反应的功能成像和鼓膜的3D成像。在过去的五年里，我的实验室建立了第一个OCT系统，能够以接近实时的帧速率(3FPS)获得人类中耳的图像。目前的提议将通过从时域OCT系统转移到去年已投入商业使用的新的无动力扫描激光系统来扩展这项工作。这种新的激光器提供了许多可以改善中耳成像的新功能-真正的实时帧速率(&gt；30FPS)、更大的扫描范围和出色的相位稳定性，适用于多普勒成像和合成孔径成像。

Optical coherence tomography (OCT) is an emerging optical imaging modality that can produce depth-resolved images of tissue. OCT is well-established in small-volume imaging applications in the retina and skin. My research is focused on its use for imaging the much larger volume of the middle ear. My proposal aims to develop techniques for fast real-time 2D imaging of the middle ear volume, Doppler OCT to enable functional imaging of the middle ear's response to sound and 3D imaging of the eardrum. Over the past five years my lab has built the first OCT system capable of obtaining images of the human middle ear at near real-time frame rates (3FPS). The current proposal will extend that work by moving from a time-domain OCT system to a new, akinetic swept-laser system that has become commercially available in the last year. This new laser offers many new capabilities that can improve middle ear imaging – true real time frame rates (>30FPS), a longer scanning range and exceptional phase stability for Doppler imaging and synthetic aperture imaging.