Advancing Molecular and Metabolic Magnetic Resonance Imaging

推进分子和代谢磁共振成像

• 批准号: 356310-2013
• 负责人: McKenzie, Charles
• 金额: $ 2.33万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=633294
• 关键词: Advancing; Molecular; Metabolic; Magnetic; Resonance

Magnetic Resonance Imaging offers tremendous opportunities for advancing medical imaging research. Unlike most other medical imaging modalities, MRI can use a wide variety of contrast mechanisms, each of which provides unique information about not only anatomical structure, but also physiological function and biochemistry. The opportunities for using MRI techniques for molecular and metabolic imaging in particular have dramatically expanded with recent developments in both chemical shift imaging techniques and the advent of hyperpolarised metabolically MRI. All of these new MRI methods show extraordinary promise for improving the detection, and staging of critically important diseases; however, there are numerous technical obstacles that must be overcome before these methods can be translated into routine clinical use. These obstacles range from development of new hardware to address shortcomings in existing technology, through the need to create new image acquisition and reconstruction methods to image hyperpolarised contrast agents. Therefore, the objectives of the proposed research are as follows: 1. Develop enhanced molecular imaging methods for the evaluation of metabolic diseases 2. Develop novel hardware to enhance clinical MRI 3. Develop accelerated imaging techniques for metabolic imaging

磁共振成像为推进医学成像研究提供了巨大的机会。与大多数其他医学成像方式不同，MRI可以使用各种各样的对比机制，每种机制不仅提供关于解剖结构的独特信息，还提供关于生理功能和生物化学的独特信息。随着化学位移成像技术的发展和超极化代谢MRI的出现，使用MRI技术进行分子和代谢成像的机会尤其显著扩大。所有这些新的MRI方法在改善关键疾病的检测和分期方面显示出非凡的前景;然而，在这些方法被转化为常规临床应用之前，必须克服许多技术障碍。这些障碍包括开发新硬件以解决现有技术中的缺点，以及需要创建新的图像采集和重建方法以使超极化造影剂成像。因此，本研究的主要目的如下：1.发展增强的分子影像学方法用于代谢性疾病的评估2.开发新的硬件以增强临床MRI 3.开发代谢成像的加速成像技术