Motion tracking and compensation techniques for medical imaging and therapeutic procedures

用于医学成像和治疗过程的运动跟踪和补偿技术

• 批准号: 342079-2013
• 负责人: Xu, Tong
• 金额: $ 1.53万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=633304
• 关键词: Motion; tracking; compensation; techniques; medical

The objective of this proposal is to develop and implement motion tracking and compensation techniques for medical imaging and therapeutic procedures. The techniques will be based on two technologies under developing by our group: positron emission based real-time tracking (PeTrack) and dynamic dual-energy x-ray imaging. The research will be carried out in the following areas: a. Radiation therapy. PeTrack can provide real-time tumour tracking with very low dose to normal tissue. It will improve the feasibility of precise respiration gated radiation therapy, tumour tracked radiation therapy , and robotic motion compensated radiosurgery. The implantation of positron emission markers, whose diameters are 0.8 mm - 0.5 mm, will be easier than the implantation of larger existing markers. Dynamic Dual-Energy Imaging can be used for lung tumour motion pre-treatment assessment at a much lower dose compared to 4D CT. b. Interventional procedures. Other procedures, such as biopsy, radiofrequency ablation, catheterization, etc, require accurate positioning of the instruments. PeTrack, as a novel tracking technique, has the advantages of being flexible, wireless and using miniature markers. It can overcome some of the limitations of current positioning techniques. c. Motion compensation for Positron Emission tomography(PET). Due to its long imaging time, PET imaging suffers from patient motion such as respiratory motion. With the accurate patient motion information provided by PeTrack, new reconstruction techniques can be developed to compensate the motion and eliminate motion artifacts. d. Functional imaging of lung. Dynamic Dual-Energy Imaging also has the potential for lung function imaging such as regional ventilation and lung kinetic study.

本提案的目的是开发和实施用于医学成像和治疗程序的运动跟踪和补偿技术。这些技术将基于我们小组正在开发的两项技术：基于正电子发射的实时跟踪（PeTrack）和动态双能X射线成像。研究将在以下几个方面进行：a。放射治疗PeTrack可以提供实时肿瘤跟踪，对正常组织的剂量非常低。它将提高精确呼吸门控放射治疗、肿瘤跟踪放射治疗和机器人运动补偿放射外科的可行性。直径为0.8 mm - 0.5 mm的正电子发射标记物的植入将比较大的现有标记物的植入更容易。与4D CT相比，动态双能量成像可以更低的剂量用于肺肿瘤运动治疗前评估。B.介入手术。其他手术，如活检、射频消融、导管插入术等，需要精确定位器械。PeTrack作为一种新型的跟踪技术，具有灵活、无线、使用微型标记等优点。它可以克服当前定位技术的一些局限性。C.正电子发射断层扫描（PET）的运动补偿。由于其长的成像时间，PET成像受到诸如呼吸运动的患者运动的影响。利用PeTrack提供的精确的患者运动信息，可以开发新的重建技术来补偿运动并消除运动伪影。D.肺功能成像。动态双能量成像还具有肺功能成像的潜力，如区域通气和肺动力学研究。