Multi-parametric vascular and metabolic MRI for the study of cerebral plasticity

用于脑可塑性研究的多参数血管和代谢 MRI

• 批准号: RGPIN-2015-04665
• 负责人: Gauthier, Claudine
• 金额: $ 1.6万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=633315
• 关键词: Multi; parametric; vascular; metabolic; MRI

The brain is known to be a highly plastic organ, meaning that it has the lifelong ability to alter its structure and function following training to learn a new task and in response to physiological changes such as injury and lifestyle (e.g. diet or exercise). For example, it has been shown using magnetic resonance imaging (MRI) that learning a motor task such as juggling can lead to changes in brain structure and function. But while we know that the brain changes, the extent of these changes, their biological nature, whether these changes are maintained in the long term and whether they can be harnessed for disease recovery are all the subject of ongoing debate. This is because brain plasticity involves multiple subtle structural, vascular and metabolic changes. These changes are notoriously difficult to study in humans using single MRI techniques and small sample sizes.

众所周知，大脑是一个高度可塑性的器官，这意味着它具有终身的能力，可以在训练后改变其结构和功能，以学习新的任务，并响应生理变化，如受伤和生活方式（例如饮食或运动）。例如，磁共振成像（MRI）显示，学习杂耍等运动任务可能会导致大脑结构和功能的变化。但是，虽然我们知道大脑会发生变化，但这些变化的程度，它们的生物学性质，这些变化是否会长期保持，以及它们是否可以用于疾病康复，都是正在进行的辩论的主题。这是因为大脑可塑性涉及多种微妙的结构、血管和代谢变化。众所周知，使用单一MRI技术和小样本量在人类中研究这些变化是非常困难的。