An optical and optoacoustics platform for laser therapeutics

用于激光治疗的光学和光声平台

• 批准号: 203234-2011
• 负责人: Whelan, William
• 金额: $ 1.6万
• 依托单位: University of Prince Edward Island
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=633317
• 关键词: optical; optoacoustics; platform; laser; therapeutics

Biomedical optics is a rapidly advancing area of research at the intersection of physics, engineering and biology that deals with the interaction of light with living systems. Optical interrogation technologies such as near-infrared radiance spectroscopy and optoacoustic imaging offer the potential for detecting tissue changes at the microstructural, biochemical and molecular levels. Research in this area is driven by the attractiveness of minimally invasive or non-invasive technologies that do not involve exposing people to ionizing radiation. The overall goal of the proposed NSERC research program is to deliver a suite of novel optical tools for optical therapeutic applications. Specifically 1) to further develop point radiance spectroscopy methods for tissue characterization; 2) to further develop optical based guiding and monitoring strategies for laser therapeutics and 3) to better understand optoacoustic contrast mechanisms in order to develop optoacoustic imaging techniques that can detect and quantify tissue response to laser therapeutics.It is anticipated that point radiance spectroscopy and the optoacoustic imaging technologies being developed will provide for improved laser therapeutics, and hence may help to accelerate these technologies into clinical practice. It is expected that this research will contribute significantly to increased economic activity through the development of new cost-effective medical technologies, provide a comprehensive platform for training of students, help raise the global profile of Canadian medical science and technology, and yield a sustainable benefit to patients whose quality of life may be improved by quantitative development of minimally invasive laser therapies.

生物医学光学是物理学、工程学和生物学交叉的一个快速发展的研究领域，研究光与生命系统的相互作用。光学询问技术，如近红外辐射光谱和光声成像提供了潜在的检测组织的变化，在微观结构，生物化学和分子水平。这一领域的研究是由不涉及使人暴露于电离辐射的微创或非侵入性技术的吸引力推动的。拟议的NSERC研究计划的总体目标是为光学治疗应用提供一套新颖的光学工具。具体而言，1）进一步开发用于组织表征的点辐射光谱法; 2）进一步开发用于激光治疗的基于光学的引导和监测策略，以及3）更好地理解光声对比机制，以便开发光声成像技术，可以检测和量化组织对激光治疗的反应。预计点辐射光谱和光声成像技术将开发的新技术将提供改进的激光疗法，因此可能有助于加速这些技术进入临床实践。预计这项研究将通过开发新的具有成本效益的医疗技术，为增加经济活动做出重大贡献，为学生培训提供全面的平台，帮助提高加拿大医学科学和技术的全球知名度，并为患者带来可持续的利益，其生活质量可以通过微创激光治疗的定量发展得到改善。