Determining the mechanism for lung lipid defects in a Mecp2-mutant mouse model for Rett syndrome

确定 Mecp2 突变小鼠 Rett 综合征模型中肺脂质缺陷的机制

• 批准号: 383417
• 负责人: Vashi Neeti
• 金额: $ 7.65万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-10-01 至 2020-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=383417&lang=en
• 关键词: Childhood Disease; Neurodevelopmental Disease; Physiology; Respiration; Rett Syndrome; X-Linked Disease

Rett syndrome (RTT) is a severe neurological disorder that almost exclusively affects females and is caused by mutations in the gene methyl-CpG-binding protein 2 (MECP2). Girls with RTT reach their normal developmental milestones, but soon lose their abil

Rett综合征（RTT）是一种严重的神经系统疾病，几乎只影响女性，由甲基CpG结合蛋白2（MECP2）基因突变引起。患有RTT的女孩达到了正常的发育里程碑，但很快就会失去能力。