Label-free imaging of biological chromophores using photothermal signatures

使用光热特征对生物发色团进行无标记成像

• 批准号: RGPIN-2015-03666
• 负责人: Tabatabaei, Nima
• 金额: $ 1.75万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=637583
• 关键词: Label; free; imaging; biological; chromophores

Optics-based imaging technologies have gained significant attention during the past three decades due to their safe non-ionizing nature and high resolving power. The source of contrast in these technologies is predominantly light scattering from tissue inhomogeneity. However, light scattering is insensitive to early disease-induced abnormalities as these changes typically initiate at the molecular level. Obtaining diagnostic contrast from light absorption is a label-free solution for improving the molecular sensitivity. The proposed research program intends to incorporate this idea to introduce new technologies as well as to enhance the current state-of-the-art in optics-based molecular-contrast imaging.

在过去的三十年里，基于光学的成像技术因其安全、非电离和高分辨率而受到极大的关注。在这些技术中，对比度的来源主要是来自组织不均匀的光散射。然而，光散射对早期疾病诱导的异常不敏感，因为这些变化通常始于分子水平。通过光吸收获得诊断对比度是一种提高分子灵敏度的无标记解决方案。拟议的研究计划旨在纳入这一想法，以引入新技术，并增强基于光学的分子对比成像的当前最先进水平。