Advancing biophysical measurements to provide a better understanding of peri-implant inflammation and to inform materials development.

金属生物材料被用作常规医疗保健的一部分，用于替代或修复丢失或受损的组织，但目前使用的材料经常与不良生物反应有关。这些事件与感染或对植入衍生物(金属表面、颗粒、离子和金属修饰的生物分子)或组合的生物反应有关。一个关键的缺陷是我们对失败的植入物周围的物理化学环境的了解。虽然有许多工业和学术主导的计划，旨在开发新的合金和表面，但我们仍然对植入金属衍生物在组织中发现的形式以及它们与哪些细胞和生物途径相互作用的了解不足。

Metallic biomaterials are used as part of routine healthcare to replace or repair lost or damaged tissues but the currently used materials are frequently associated with adverse biological responses. These events are linked to either infection or to biological responses to implant derivatives (metal surfaces, particles, ions, and metal modified bio-molecules) or a combination. A key deficiency is our understanding of the physico-chemical environment which develops around the failing implant. Whilst there are numerous industrial and academic led programs aiming to develop new alloys and surfaces we still have an inadequate understanding of the form implant metal derivatives are found in tissues and with which cells and biological pathways they interact.