Mutliscale Mechanics, Mechanobiology and Imaging of Musculoskeletal Tissues

肌肉骨骼组织的多尺度力学、力学生物学和成像

• 批准号: RGPIN-2017-04841
• 负责人: Duncan, Neil
• 金额: $ 1.6万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638522
• 关键词: Mutliscale; Mechanics; Mechanobiology; Imaging; Musculoskeletal

The musculoskeletal system functions primarily to enable mobility and transmit mechanical loads, yet also has the ability of biological tissues to maintain and repair itself throughout life. Degenerative disc disease, osteoarthritis, osteoporosis, and repetitive loading syndromes are some of the most prevalent causes of morbidity in the Western world, which will likely increase in prevalence with an aging population. Mechanical factors, such as repetitive lifting tasks and acute overloading, have long been implicated in the etiology of musculoskeletal disorders. Connective tissues such as intervertebral disc, articular cartilage and tendon are altered at multiple scales biologically, biochemically and biomechanically with ageing, degeneration and injury. To understand the role of mechanical, biological and genetic factors in musculoskeletal disorders requires the detailed knowledge of how the cells interact

肌肉骨骼系统的功能主要是使运动和传递机械负荷，但也有生物组织的能力，以维持和修复自己在整个生命。退行性椎间盘疾病、骨关节炎、骨质疏松症和重复负荷综合征是西方世界最常见的发病原因，随着人口老龄化，这些疾病的患病率可能会增加。机械因素，如重复性举重任务和急性超负荷，长期以来一直与肌肉骨骼疾病的病因有关。结缔组织如椎间盘、关节软骨和肌腱在生物学、生物化学和生物力学上随着衰老、退化和损伤而在多个尺度上改变。要了解肌肉骨骼疾病中机械、生物和遗传因素的作用，需要详细了解细胞如何相互作用