Influence of the operating frequency and amplitude in an acoustic airway clearance device

Dymedso公司(Boisbriand，QC)制造Fredencer(TM)，这是一种数字控制的声道清除设备，通过诱导患者胸壁的振动来促进支气管引流。Fredencer(TM)推荐给患有粘液纤毛清除缺陷的患者，包括囊性纤维化(CF)、慢性支气管炎、胸壁缺陷和其他病理疾病。Fredencer(TM)的工作频率为20至65赫兹，与传统的“拍手”方法或体位引流相比，它提供了一种更温和的治疗方法。Dymedso希望给声称在37至42赫兹频率下有更好的粘液流动性的客户一个答案。CF患者的粘液流动性不足可归因于其脱水，即氯化钠排入呼吸道的顺序不充分，导致分泌物粘度增加。在拟议的项目中，我们将进行一系列测试，以阐明在不同工作频率和功率下，粘蛋白溶液中水和盐(氯化钠)传输的可能机制。在含有水和粘蛋白溶液与盐的两相混合物的AAD-HOC反应器的顶部应用Frequencer(TM)头将实现这一目标。除了人工粘液中的水和盐浓度在不同的频率和功率的频率(TM)暴露后，我们将量化粘液流变行为的变化，并开发一个通过粘蛋白溶液的水和盐传质的数值模型。

The company Dymedso (Boisbriand, QC) manufactures The Frequencer(TM), a digitally controlled acousticairway clearance device that promotes bronchial drainage by inducing vibrations in the chest wall of a patient.The Frequencer(TM) is recommended for patients affected by defective mucociliary clearance including cysticfibrosis (CF), chronic bronchitis, thoracic wall defects among other pathologies. With an operating frequencyof 20 to 65 Hz, The Frequencer(TM) provides a gentler therapy than the traditional "clapping" method orpostural drainage. Dymedso is looking to give an answer to its customers who claim a better mucous fluidity atfrequencies of 37 to 42 Hz. The lack of mucous fluidity in patients with CF is ascribable to its dehydration as aconsequence of insufficient excretion of NaCl to the airways, leading to the increase of secretion viscosity. Inthe project proposed we will realize a series of tests to elucidate possible mechanisms underlying the transportof water and salt (NaCl) in mucin solutions at different operating frequencies and powers of TheFrequencer(TM). The objective will be achieved applying the head of The Frequencer(TM) to the top of aad-hoc reactor containing biphasic mixtures of water and mucin solutions with salt. Besides water and saltconcentration in the artificial mucous after exposure to different operating frequencies and powers of theFrequencer(TM), we will quantify changes in mucous rheological behavior and develop a numerical model forwater and salt mass transfer through the mucin solutions.