Development of a Computational Fluid Dynamics Model of a Jet Nebulizer Device for Aerosol Drug Delivery

用于气雾剂药物输送的喷射雾化器装置的计算流体动力学模型的开发

• 批准号: 520591-2017
• 负责人: DeGroot, Christopher
• 金额: $ 1.82万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639932
• 关键词: Development; Computational; Fluid; Dynamics; Model

A nebulizer is a type of drug delivery device that provides medication in the form of an aerosol that can beinhaled into the lungs and absorbed into the bloodstream. They are typically used to treat respiratory illnessessuch as chronic obstructive pulmonary disorder and asthma. Nebulizers operate by taking a medication inliquid form, transforming it into small aerosol droplets of a particular size, and delivering those droplets to themouth of the patient for inhalation. There are several different types of nebulizer, the most common of which isthe jet nebulizer, which will be studied during the proposed project. These operate through the use of ahigh-speed jet of compressed gas, which entrains the liquid and converts it to an aerosol, typically by collidingthe liquid droplets with a baffle.This project seeks to provide a better understanding of the operation of jet nebulizers from a fluid mechanicsperspective. To provide this understanding, a computational fluid dynamics (CFD) model will be developed tomodel the flow patterns in the device, and their role in the formation and delivery of aerosol particles. This willallow for optimization of nebulizer devices, which can lead to better utilization of the drug and shortertreatment times for patients. Ultimately, by improving the medical devices that treat respiratory illnesses, thepatients' conditions can be better managed, allowing them to lead better lives.

雾化器是一种药物输送装置，以气雾剂的形式提供药物，可以吸入肺部并吸收到血液中。它们通常用于治疗呼吸系统疾病，如慢性阻塞性肺病和哮喘。雾化器的工作原理是将液体形式的药物转化为特定大小的小气雾剂液滴，并将这些液滴输送到患者的口中吸入。有几种不同类型的雾化器，其中最常见的是喷射雾化器，这将在拟议的项目中进行研究。这些通过使用压缩气体的高速喷射来操作，该喷射夹带液体并将其转化为气溶胶，通常通过将液滴与挡板碰撞来实现。为了提供这种理解，将开发计算流体动力学（CFD）模型来模拟装置中的流动模式，以及它们在气溶胶颗粒的形成和输送中的作用。这将允许优化雾化器装置，从而更好地利用药物并缩短患者的治疗时间。最终，通过改善治疗呼吸道疾病的医疗设备，患者的病情可以得到更好的控制，让他们过上更好的生活。