Development of a computational fluid dynamics model of a jet nebulizer device for aerosol drug delivery

用于气雾剂药物输送的喷射雾化器装置的计算流体动力学模型的开发

• 批准号: 536682-2018
• 负责人: DeGroot, Christopher
• 金额: $ 0.73万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=648919
• 关键词: Development; computational; fluid; dynamics; model

A nebulizer is a type of drug delivery device that provides medication in the form of an aerosol that can be**inhaled into the lungs and absorbed into the bloodstream. They are typically used to treat respiratory illnesses**such as chronic obstructive pulmonary disorder and asthma. Nebulizers operate by taking a medication in**liquid form, transforming it into small aerosol droplets of a particular size, and delivering those droplets to the**mouth of the patient for inhalation. There are several different types of nebulizer, the most common of which is**the jet nebulizer, which will be studied during the proposed project. These operate through the use of a**high-speed jet of compressed gas, which entrains the liquid and converts it to an aerosol, typically by colliding**the liquid droplets with a baffle.**This project seeks to provide a better understanding of the operation of jet nebulizers from a fluid mechanics**perspective. To provide this understanding, a computational fluid dynamics (CFD) model is being developed**and validated to model the flow patterns in the device, and their role in the formation and delivery of aerosol**particles. This will allow for optimization of nebulizer devices, which can lead to better utilization of the drug**and shorter treatment times for patients. This particular phase of the project is focused on validation of the CFD**model using experimental methods, and subsequent improvement of the model developed in the previous**phase. Ultimately, by improving the medical devices that treat respiratory illnesses, the patients' conditions can**be better managed, allowing them to lead better lives.

雾化器是一种药物输送装置，以气雾剂的形式提供药物，可以吸入肺部并吸收到血液中。它们通常用于治疗呼吸系统疾病 **，如慢性阻塞性肺病和哮喘。雾化器的工作原理是将药物以液体形式吸入，将其转化为特定大小的小气雾剂液滴，并将这些液滴输送到患者的口腔中吸入。有几种不同类型的雾化器，其中最常见的是 ** 喷射雾化器，将在拟议项目期间进行研究。这些通过使用压缩气体的高速喷射来操作，该喷射夹带液体并将其转化为气溶胶，通常通过使液滴与挡板碰撞来实现。这个项目旨在从流体力学的角度提供对喷射雾化器操作的更好理解。为了提供这种理解，正在开发计算流体动力学（CFD）模型 **，并验证该模型，以模拟设备中的流动模式及其在气溶胶 ** 颗粒形成和输送中的作用。这将允许优化雾化器装置，从而更好地利用药物 ** 并缩短患者的治疗时间。该项目的这一特定阶段的重点是使用实验方法验证CFD** 模型，并对上一 ** 阶段开发的模型进行后续改进。最终，通过改善治疗呼吸道疾病的医疗设备，患者的病情可以得到更好的管理，使他们过上更好的生活。