Development of a computational fluid dynamics model of a jet nebulizer device for aerosol drug delivery

雾化器是一种药物输送装置，它以气雾剂的形式提供药物，可以**吸入到肺部，并被吸收到血液中。它们通常用于治疗呼吸系统疾病**，如慢性阻塞性肺疾病和哮喘。雾化器的工作原理是服用**液体形式的药物，将其转化为特定大小的小气雾剂液滴，并将这些液滴送到患者的**口腔进行吸入。有几种不同类型的雾化器，其中最常见的是**喷射雾化器，这将在拟议的项目中进行研究。这些技术是通过使用**高速压缩气体射流来运行的，这种高速射流携带液体并将其转化为气溶胶，通常是通过**液体液滴与挡板的碰撞。**本项目旨在从流体力学**的角度更好地了解喷射雾化器的工作原理。为了提供这种理解，正在开发一种计算流体动力学(CFD)模型，**并验证该模型，以模拟设备中的流动模式，以及它们在气溶胶颗粒**形成和输送中的作用。这将允许优化雾化器设备，从而可以更好地利用药物**并缩短患者的治疗时间。该项目的这一特定阶段侧重于使用实验方法验证CFD**模型，并随后改进前一**阶段开发的模型。最终，通过改进治疗呼吸系统疾病的医疗设备，可以**更好地管理患者的病情，使他们能够过上更好的生活。

A nebulizer is a type of drug delivery device that provides medication in the form of an aerosol that can be**inhaled into the lungs and absorbed into the bloodstream. They are typically used to treat respiratory illnesses**such as chronic obstructive pulmonary disorder and asthma. Nebulizers operate by taking a medication in**liquid form, transforming it into small aerosol droplets of a particular size, and delivering those droplets to the**mouth of the patient for inhalation. There are several different types of nebulizer, the most common of which is**the jet nebulizer, which will be studied during the proposed project. These operate through the use of a**high-speed jet of compressed gas, which entrains the liquid and converts it to an aerosol, typically by colliding**the liquid droplets with a baffle.**This project seeks to provide a better understanding of the operation of jet nebulizers from a fluid mechanics**perspective. To provide this understanding, a computational fluid dynamics (CFD) model is being developed**and validated to model the flow patterns in the device, and their role in the formation and delivery of aerosol**particles. This will allow for optimization of nebulizer devices, which can lead to better utilization of the drug**and shorter treatment times for patients. This particular phase of the project is focused on validation of the CFD**model using experimental methods, and subsequent improvement of the model developed in the previous**phase. Ultimately, by improving the medical devices that treat respiratory illnesses, the patients' conditions can**be better managed, allowing them to lead better lives.