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Global mapping of metabolic genetic interaction networks using CRISPR-Cas screens to reveal novel cancer vulnerabilities and biomarkers

Global mapping of metabolic genetic interaction networks using CRISPR-Cas screens to reveal novel cancer vulnerabilities and biomarkers
使用 CRISPR-Cas 屏幕绘制代谢遗传相互作用网络的全局图谱,以揭示新的癌症脆弱性和生物标志物
批准号:
383223
负责人:
Aregger Michael
金额:
$0.07万
依托单位:
依托单位国家:
加拿大
项目类别:
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-02-01 至 2019-02-01

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Cancer cells reshape their metabolism to meet the increased demand for the building blocks required to fuel rapid growth and proliferation, which provides a unique target for cancer therapeutic intervention. Indeed, several drugs that inhibit metabolic re
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