Cancer Metabolism Core

癌症代谢核心

基本信息

项目摘要

METABOLISM CORE Abstract The metabolism core of the proposed the UNMC Acquired Resistance to Therapy Network (ARTNet) Center for Pancreatic Cancer (ACPC) will study innovative, hypothesis-driven mechanisms of metabolic and signaling alterations that contribute to acquired therapy resistance in pancreatic ductal adenocarcinoma (PDAC). The core services provided by the metabolism core will be well integrated into all the three projects. The core will offer cost-effective metabolomics and data analysis support with appropriate quality controls for all projects by providing a centralized infrastructure and expertise in metabolomics, physiological assays, and metabolic dependency/vulnerability screens. The metabolism core will have three specific aims. The basic capabilities offered by the Core will include steady-state polar metabolomics and lipidomics (Specific Aim 1), Stable Isotope Resolved Metabolomics (SIRM) with kinetic flux analysis (Specific Aim 2), and Seahorse extracellular flux analyzer-based assays, fluorescent assays to investigate the metabolic state of cells, and identifying metabolic vulnerabilities (Specific Aim 3). The Metabolism Core will participate in the design and conduct of steady-state polar metabolomics, lipidomics, 13C-metabolite labeled kinetic flux analysis with cell lines, organoids, and exosomes. The core will also perform steady-state polar metabolomics and lipidomics for mouse and human tumor tissue specimens in all the projects. The core will also provide hands-on training, as needed, for the ACPC, other ARTNet centers, and other investigators. The core will also provide support for measuring drug concentrations and metabolism in the tissues and drug pharmacokinetics/ pharmacodynamics studies.
代谢的核心

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Pankaj Kumar Singh其他文献

Utilization of wastewater as nutrient media and biomass valorization in marine Chrysophytes- Chaetoceros and Isochrysis
废水作为营养介质的利用和海洋金藻植物-角毛藻和等鞭金藻的生物量增值
  • DOI:
    10.1016/j.ecmx.2020.100062
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Pankaj Kumar Singh;Raya Bhattacharjya;A. Saxena;Bharti Mishra;A. Tiwari
  • 通讯作者:
    A. Tiwari
Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer
  • DOI:
    10.1016/j.jconrel.2022.05.034
  • 发表时间:
    2022-08-01
  • 期刊:
  • 影响因子:
    11.500
  • 作者:
    Ujala Gupta;Brojendra Nath Saren;Kedar Khaparkhuntikar;Jitender Madan;Pankaj Kumar Singh
  • 通讯作者:
    Pankaj Kumar Singh
Long Segment Bony Spur in Split Cord Malformation Type 1
  • DOI:
    10.1007/s12098-016-2244-6
  • 发表时间:
    2016-10-22
  • 期刊:
  • 影响因子:
    2.000
  • 作者:
    Kanwaljeet Garg;Pankaj Kumar Singh;Shashank Sharad Kale;Bhawani Shankar Sharma
  • 通讯作者:
    Bhawani Shankar Sharma
Pediatric intracranial aneurysms—our experience and review of literature
  • DOI:
    10.1007/s00381-013-2336-9
  • 发表时间:
    2013-12-10
  • 期刊:
  • 影响因子:
    1.200
  • 作者:
    Kanwaljeet Garg;Pankaj Kumar Singh;Bhawani Shankar Sharma;Poodipedi Sarat Chandra;Ashish Suri;Manmohanjit Singh;Rajinder Kumar;Shashank Sarad Kale;Nalin Kumar Mishra;Shailesh K Gaikwad;Ashok Kumar Mahapatra
  • 通讯作者:
    Ashok Kumar Mahapatra
Spontaneously Disappearing Pineal Region Mass: A Rare Manifestation of Vein of Galen Malformation
  • DOI:
    10.1007/s12098-014-1537-x
  • 发表时间:
    2014-08-08
  • 期刊:
  • 影响因子:
    2.000
  • 作者:
    Amandeep Kumar;Gopal Krishna;Pankaj Kumar Singh;Ajay Garg;Bhawani S. Sharma
  • 通讯作者:
    Bhawani S. Sharma

Pankaj Kumar Singh的其他文献

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{{ truncateString('Pankaj Kumar Singh', 18)}}的其他基金

Metabolic regulation of FOLFIRINOX acquired resistance in pancreatic cancer
FOLFIRINOX 在胰腺癌中获得性耐药的代谢调节
  • 批准号:
    10518247
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:
Pancreatic Cancer ARTNet Center
胰腺癌 ARTNet 中心
  • 批准号:
    10707504
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10518244
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:
Pancreatic Cancer ARTNet Center
胰腺癌 ARTNet 中心
  • 批准号:
    10518243
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:
Cancer Metabolism Core
癌症代谢核心
  • 批准号:
    10518246
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:
Metabolic regulation of FOLFIRINOX acquired resistance in pancreatic cancer
FOLFIRINOX 在胰腺癌中获得性耐药的代谢调节
  • 批准号:
    10707541
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10707537
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:
Molecular Basis of ME2-mediated Tumor Suppression in Pancreatic Cancer
ME2 介导的胰腺癌肿瘤抑制的分子基础
  • 批准号:
    10671029
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:
Mitochondrial calcium signaling in pancreatic cancer metastasis and progression
胰腺癌转移和进展中的线粒体钙信号传导
  • 批准号:
    10363987
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:
Mitochondrial calcium signaling in pancreatic cancer metastasis and progression
胰腺癌转移和进展中的线粒体钙信号传导
  • 批准号:
    10565949
  • 财政年份:
    2022
  • 资助金额:
    $ 9.37万
  • 项目类别:

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利用水螅刺丝囊部署建立新的生物测定方法
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    2017
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基于使用酵母敲除菌株收集的新生物测定系统的药物发现
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