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Integration of distinct ShcA signaling complexes promotes breast tumor growth and tyrosine kinase inhibitor resistance

Integration of distinct ShcA signaling complexes promotes breast tumor growth and tyrosine kinase inhibitor resistance
不同 ShcA 信号复合物的整合促进乳腺肿瘤生长和酪氨酸激酶抑制剂耐药性
批准号：
383146
负责人：
Ha Jacqueline R
金额：
$0.07万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-02-01 至 2019-02-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=383146&lang=en
关键词：
Ics Travel Awards

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INTRODUCTION: When a cell acquires mutations that alter the levels and/or function of specific proteins, there is rapid unrestricted cell division ultimately leading to cancer. Cell division is largely regulated by DNA, the instructions for protein produc
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Elucidation of the Role of ShcA as a Biological Sensor of Receptor Tyrosine Kinase Signaling in Breast Cancer