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Elucidation of the Role of ShcA as a Biological Sensor of Receptor Tyrosine Kinase Signaling in Breast Cancer

Elucidation of the Role of ShcA as a Biological Sensor of Receptor Tyrosine Kinase Signaling in Breast Cancer
阐明 ShcA 作为乳腺癌受体酪氨酸激酶信号传导生物传感器的作用
批准号：
327915
负责人：
Ha Jacqueline R
金额：
$7.65万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-10-01 至 2017-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=327915&lang=en
关键词：
Breast Cancer Cell Signalling Mouse Models/Transgenics Receptor Tyrosine Kinase Signalling Shca Translation Research

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INTRODUCTION: When a cell acquires mutations that alter the levels and/or function of specific proteins, there is rapid unrestricted cell division ultimately leading to cancer. Cell division is largely regulated by DNA, the instructions for protein produc
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Integration of distinct ShcA signaling complexes promotes breast tumor growth and tyrosine kinase inhibitor resistance
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