Macromolecular interaction analysis using a surface plasmon resonance biosensor

使用表面等离子体共振生物传感器进行大分子相互作用分析

• 批准号: RTI-2018-00894
• 负责人: Pascal, John
• 金额: $ 10.82万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642170
• 关键词: Macromolecular; interaction; analysis; using; surface

Multiple investigators in the Department of Biochemistry and Molecular Medicine at the Université de Montréal (UdeM) are studying molecular interactions that drive fundamental biological processes, such as replication and repair of DNA, biogenesis of microRNA, evolutionary biology and drug resistance, metabolism of mercury compounds by bacterial enzymes, and the biophysics of protein condensates in cellular organization. Their NSERC-funded research programs train highly-qualified personnel to identify and interrogate the basis of biomolecular interactions, thus providing critical insights into the forces that underlie signaling networks, multi-component complexes, and small-molecule binding events. These research activities provide training in specialized skills that are highly valued in key job sectors such as the pharmaceutical and biotech industries. To fully understand the specificity and dynamics of complex molecular interactions, multiple experimental approaches are required to capitalize on the strengths and mitigate the limitations inherent to each technique.

蒙特利尔大学生物化学和分子医学系的多名研究人员正在研究驱动基本生物学过程的分子相互作用，如DNA的复制和修复、microRNA的生物发生、进化生物学和耐药性、细菌酶对汞化合物的代谢，以及细胞组织中蛋白质凝聚体的生物物理。他们的NSERC资助的研究项目培训高素质的人员来识别和询问生物分子相互作用的基础，从而为信号网络、多组分复合体和小分子结合事件背后的力量提供关键的见解。这些研究活动提供在制药和生物技术行业等关键工作部门高度重视的专门技能培训。为了充分了解复杂分子相互作用的特殊性和动力学，需要多种实验方法来充分利用每种技术的优势并减轻其固有的限制。