Tendon cell mechanotransduction

肌腱细胞力转导

• 批准号: RTI-2018-00345
• 负责人: Scott, Alexander
• 金额: $ 3.07万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642183
• 关键词: Tendon; cell; mechanotransduction

This proposal is a sole investigator request for specialized infrastructure to biomechanically stimulate human tendon cells via specific cell surface receptors. The requested equipment incorporates a magnetic force bioreactor, compatible cell culture array plates, and antibody-coated magnetic microbeads. This unique system, developed at Keele university and recently made commercially available through a unique supplier (MICA Biosystems), will allow physiologically relevant mechanical forces to be delivered to tendon cells via cell surface mechanoreceptors. This technology will enable a crucial step forward in understanding the mechanisms of tendon adaptation, which can then be applied in the design of new exercise programs.

这一建议是唯一的研究者要求专门的基础设施，以生物力学刺激人类肌腱细胞通过特定的细胞表面受体。所要求的设备包括磁力生物反应器、兼容的细胞培养阵列板和抗体包被的磁微珠。这种独特的系统由基尔大学开发，最近通过一家独特的供应商（MICA Biosystems）商业化，将允许通过细胞表面机械感受器将生理相关的机械力传递给肌腱细胞。这项技术将使理解肌腱适应机制向前迈出关键一步，然后将其应用于新的锻炼计划的设计。