Tendon cell mechanotransduction

该提案是唯一的研究者要求专门的基础设施，通过特定的细胞表面受体生物力学刺激人类肌腱细胞。申请的设备包括磁力生物反应器、兼容的细胞培养阵列板和抗体包被的磁性微珠。这个独特的系统，在基尔大学开发，最近通过一个独特的供应商（云母Biosystems）商业化，将允许生理相关的机械力通过细胞表面机械感受器传递到肌腱细胞。这项技术将在理解肌腱适应机制方面迈出关键一步，然后可以应用于设计新的锻炼计划。

This proposal is a sole investigator request for specialized infrastructure to biomechanically stimulate human tendon cells via specific cell surface receptors. The requested equipment incorporates a magnetic force bioreactor, compatible cell culture array plates, and antibody-coated magnetic microbeads. This unique system, developed at Keele university and recently made commercially available through a unique supplier (MICA Biosystems), will allow physiologically relevant mechanical forces to be delivered to tendon cells via cell surface mechanoreceptors. This technology will enable a crucial step forward in understanding the mechanisms of tendon adaptation, which can then be applied in the design of new exercise programs.