Inert-Atmosphere Workstation to Enable New Advances in Catalytic Borylation and Cross-Coupling Reactions

惰性气氛工作站使催化硼化和交叉偶联反应取得新进展

• 批准号: RTI-2018-00082
• 负责人: Hall, Dennis
• 金额: $ 2.03万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642241
• 关键词: Inert; Atmosphere; Workstation; Enable; New

With discoveries like drugs, insecticides, polymers, and food additives, organic chemistry is a powerful science that has helped our modern society enjoy a dramatic increase in life expectancy and standard of living in the past century. The discovery of new drugs and commodity chemicals rely on a continuous input of new reactions, new reagents, and new catalysts (catalysts are species, used in a small amount, that enable and/or accelerate chemical reactions). This RTI grant application describes a proposal to acquire a basic, compact, inert-atmosphere glove box with a refrigerator unit for my laboratory. In organometallic chemistry, ready access to a glove box is crucial in order to develop and optimize new reaction processes using water- and air-sensitive catalysts, ligands, and reactants. Our urgent need for a glove box is acutely exemplified with three ongoing projects in my laboratory involving the development of innovative transition metal-catalyzed borylation reactions to provide new and effective ways to prepare pharmaceutically important intermediates such as polysubstituted piperidines and chiral boronates. Two of these projects, which are currently delayed for lack of a glove box, were at the heart of the P.I.'s recently approved Discovery Grant application and the success of these projects relies on this attendant RTI application for a glove box. This instrument will greatly enhance the training environment of at least 4-5 co-workers in the P.I.'s research group who will develop important technical skills of great importance for employment in the pharmaceutical and chemical industry.

随着药物，杀虫剂，聚合物和食品添加剂的发现，有机化学是一门强大的科学，帮助我们的现代社会在过去的世纪中大幅提高了预期寿命和生活水平。新药和化学品的发现依赖于新反应、新试剂和新催化剂的持续输入（催化剂是少量使用的物质，能够实现和/或加速化学反应）。这个RTI资助申请描述了一个为我的实验室购买一个基本的、紧凑的、带冰箱的惰性气氛手套箱的建议。在有机金属化学中，为了使用水和空气敏感的催化剂、配体和反应物开发和优化新的反应过程，手套箱的方便使用至关重要。我们迫切需要一个手套箱是尖锐的例子，在我的实验室正在进行的三个项目，涉及创新的过渡金属催化硼化反应的发展，提供新的和有效的方法来制备药学上重要的中间体，如多取代哌啶和手性硼酸酯。其中两个项目，目前因缺乏手套箱而被推迟，是P.I.的核心。的最近批准的发现补助金申请和这些项目的成功依赖于这个服务员RTI申请手套箱。该工具将大大改善P.I.中至少4-5名同事的培训环境。的研究小组谁将开发重要的技术技能，非常重要的就业在制药和化工行业。