Inert-Atmosphere Workstation to Enable New Advances in Catalytic Borylation and Cross-Coupling Reactions

随着药物、杀虫剂、聚合物和食品添加剂等的发现，有机化学是一门强大的科学，在过去的一个世纪里，它帮助我们现代社会的预期寿命和生活水平大幅提高。新药和商品化学品的发现依赖于新反应、新试剂和新催化剂的不断投入（催化剂是一种少量使用的能使和/或加速化学反应的物质）。这个RTI拨款申请描述了为我的实验室获得一个基本的、紧凑的、带冰箱单元的惰性气氛手套箱的建议。在有机金属化学中，为了开发和优化使用水和空气敏感催化剂、配体和反应物的新反应过程，准备好手套箱是至关重要的。我们对手套箱的迫切需求，在我的实验室中有三个正在进行的项目，涉及发展创新的过渡金属催化的硼化反应，为制备药学上重要的中间体，如多取代哌啶和手性硼酸盐，提供新的和有效的方法。这些项目中有两个目前因缺少手套箱而被推迟，但它们是P.I.的核心这些项目的成功依赖于这个伴随的RTI手套箱申请。该仪器将极大地改善至少4-5名pi同事的培训环境他们将培养对制药和化工行业就业非常重要的重要技术技能。

With discoveries like drugs, insecticides, polymers, and food additives, organic chemistry is a powerful science that has helped our modern society enjoy a dramatic increase in life expectancy and standard of living in the past century. The discovery of new drugs and commodity chemicals rely on a continuous input of new reactions, new reagents, and new catalysts (catalysts are species, used in a small amount, that enable and/or accelerate chemical reactions). This RTI grant application describes a proposal to acquire a basic, compact, inert-atmosphere glove box with a refrigerator unit for my laboratory. In organometallic chemistry, ready access to a glove box is crucial in order to develop and optimize new reaction processes using water- and air-sensitive catalysts, ligands, and reactants. Our urgent need for a glove box is acutely exemplified with three ongoing projects in my laboratory involving the development of innovative transition metal-catalyzed borylation reactions to provide new and effective ways to prepare pharmaceutically important intermediates such as polysubstituted piperidines and chiral boronates. Two of these projects, which are currently delayed for lack of a glove box, were at the heart of the P.I.'s recently approved Discovery Grant application and the success of these projects relies on this attendant RTI application for a glove box. This instrument will greatly enhance the training environment of at least 4-5 co-workers in the P.I.'s research group who will develop important technical skills of great importance for employment in the pharmaceutical and chemical industry.