Boron Chemistry for Catalysis and Drug Discovery

用于催化和药物发现的硼化学

• 批准号: CRC-2015-00074
• 负责人: Hall, Dennis
• 金额: $ 14.57万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=652841
• 关键词: Boron; Chemistry; Catalysis; Drug; Discovery

Organoboron chemistry, the study of organic compounds containing carbon-boron bonds, plays a key role by providing chemical reactions that are changing the way *synthetic drugs are produced in the pharmaceutical industry. The nominee is an expert on fundamental research and applications of boronic acids, a stable and *convenient class of boron compounds that display unique properties and can be turned reactive under the right conditions. Using novel chemistry of boronic acids, *the goal of the proposed program is two-fold: 1) to invent new reactions and new catalysts to achieve or improve chemical reactions that are environmentally friendlier *("greener") and more cost-effective, 2) to translate these discoveries into solutions for real-life problems in areas such as human health (i.e., cancer *chemotherapeutics). These challenges will be tackled by developing novel carbon-carbon bond forming reactions to access and optimize classes of molecules that *display anticancer properties.

有机硼化学，研究含有碳-硼键的有机化合物，通过提供改变制药工业中合成药物生产方式的化学反应发挥着关键作用。被提名人是硼酸基础研究和应用方面的专家，硼酸是一类稳定而方便的硼化合物，具有独特的性质，在适当的条件下可以转化为反应性。 使用硼酸的新化学，* 拟议计划的目标是双重的：1）发明新的反应和新的催化剂，以实现或改善环境友好 *（“绿色”）和更具成本效益的化学反应，2）将这些发现转化为人类健康等领域的现实问题的解决方案（即，癌症 * 化学疗法）。这些挑战将通过开发新的碳-碳键形成反应来解决，以获得和优化显示抗癌特性的分子类别。