Boron Chemistry for Catalysis and Drug Discovery

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Organoboron chemistry, the study of organic compounds containing carbon-boron bonds, plays a key role by providing chemical reactions that are changing the way *synthetic drugs are produced in the pharmaceutical industry. The nominee is an expert on fundamental research and applications of boronic acids, a stable and *convenient class of boron compounds that display unique properties and can be turned reactive under the right conditions. Using novel chemistry of boronic acids, *the goal of the proposed program is two-fold: 1) to invent new reactions and new catalysts to achieve or improve chemical reactions that are environmentally friendlier *("greener") and more cost-effective, 2) to translate these discoveries into solutions for real-life problems in areas such as human health (i.e., cancer *chemotherapeutics). These challenges will be tackled by developing novel carbon-carbon bond forming reactions to access and optimize classes of molecules that *display anticancer properties.