Chemical Sensing

化学传感

• 批准号: 1000228971-2012
• 负责人: Algar, Russ
• 金额: $ 7.29万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642914
• 关键词: Chemical; Sensing

The Algar Research Program focuses on developing nanoparticle-based biosensors and cellular probes. Nanoparticles represent a new frontier in biosensing by virtue of their unique properties and small size. We seek to exploit these characteristics in developing new bioanalytical tools that can (1) measure panels of multiple, clinically relevant biomarkers at points of patient care; (2) elucidate complex biochemical processes in cells through real-time visualization and quantitative measurements; and (3) provide concurrent diagnostic and therapeutic utility. Our current focus is on harnessing brightly luminescent quantum dot nanoparticles as platforms to detect protease enzymes. Irregularities associated with these enzymes are implicated in many diseases.

Algar研究计划的重点是开发基于纳米颗粒的生物传感器和细胞探针。纳米粒子凭借其独特的性质和小尺寸代表了生物传感的新前沿。我们试图利用这些特性开发新的生物分析工具，这些工具可以（1）在患者护理点测量多种临床相关生物标志物的面板;（2）通过实时可视化和定量测量阐明细胞中复杂的生化过程;（3）提供并行诊断和治疗效用。我们目前的重点是利用明亮发光的量子点纳米粒子作为平台来检测蛋白酶。与这些酶相关的刺激与许多疾病有关。