Eukaryotic Cellular Signaling

真核细胞信号转导

• 批准号: CRC-2015-00145
• 负责人: Jones, Nina
• 金额: $ 7.29万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=643152
• 关键词: Eukaryotic; Cellular; Signaling

Multicellular organisms rely on signal transduction cascades to control important biological responses such as cell growth, differentiation and survival. Understanding the biochemical basis of these protein-protein interactions is of key importance in defining how particular mutations can contribute to pathological conditions. This research program uses a multi-disciplinary approach to investigate the molecular mechanisms that underlie cellular communication. This research is cutting edge and fundamental to understanding aspects of development, kidney function, blood vessel formation and nervous system patterning, and the discoveries may ultimately contribute to the establishment of new treatment strategies for human pathologies such as renal disease and cancer.

多细胞生物体依赖于信号转导级联来控制重要的生物反应，例如细胞生长、分化和存活。了解这些蛋白质-蛋白质相互作用的生化基础对于确定特定突变如何导致病理状况至关重要。该研究计划使用多学科方法来研究细胞通讯的分子机制。这项研究对于了解发育、肾脏功能、血管形成和神经系统模式等方面具有前沿性和基础性，这些发现最终可能有助于为肾脏疾病和癌症等人类病理建立新的治疗策略。