Epigenetic coordination of transcriptional and translational programs in hypoxia

缺氧条件下转录和翻译程序的表观遗传协调

• 批准号: 380990
• 负责人: Postovit Lynne-Marie
• 金额: $ 80.81万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-03-01 至 2023-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=380990&lang=en
• 关键词: Breast Cancer; Epigenetics; Hypoxia; Metastasis; Transcriptional Start Site; Translation

Low oxygen levels (hypoxia) are common in cancers, such as breast cancer, and have been shown to cause breast cancers to spread (metastasize). In order to grow and spread breast cancer cells must adapt. If we understand how breast cancer cells adapt we ca

低氧水平（缺氧）在癌症中很常见，如乳腺癌，并已被证明会导致乳腺癌的扩散（转移）。为了生长和扩散，乳腺癌细胞必须适应环境。如果我们了解乳腺癌细胞是如何适应的，我们就能