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Molecular evolution of self-nonself discrimination by paired NKR-P1 receptors, self ligands, and viral immunoevasins

Molecular evolution of self-nonself discrimination by paired NKR-P1 receptors, self ligands, and viral immunoevasins
成对 NKR-P1 受体、自身配体和病毒免疫逃避蛋白的自我-非自我歧视的分子进化
批准号：
382745
负责人：
Carlyle James R
金额：
$47.37万
依托单位：
Sunnybrook Research Institute (Toronto, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-03-01 至 2023-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=382745&lang=en
关键词：
Co-Evolution Host-Pathogen Interactions Immunoevasin Innate Immunity Mouse Cytomegalovirus Natural Killer Cell Nkr-P1:Clr Self-Nonself Discrimination Viral Immune Evasion X-Ray Crystal Structure

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The innate immune system protects us from pathogenic bacteria, viruses, and cancer, and also helps to maintain normal tissue function at mucosal barriers, such as the skin, gut, and lungs. Natural killer (NK) cells are a subset of innate lymphoid cells (I
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