Cancer Therapy exploiting Conditional Synthetic Lethality based on Genotoxic Stress levels

利用基于基因毒性应激水平的条件合成致死率的癌症治疗

• 批准号: 380785
• 负责人: Gamper Armin
• 金额: $ 66.88万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-03-01 至 2023-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=380785&lang=en
• 关键词: Breast Cancer; Cell Cycle Checkpoints; Dna Damage Response; Mouse Xenograft Models; Replication Stress; Synthetic Lethality

Because cancer cells have lost checkpoints that healthy cells have, they have increased levels of DNA damage. This DNA damage causes particular problems during replication, when cells make a copy of their DNA. (When a cell divides, both cells should have

由于癌细胞失去了健康细胞所拥有的检查点，它们增加了DNA损伤的水平。当细胞复制自己的DNA时，这种DNA损伤会在复制过程中造成特殊的问题。(当细胞分裂时，两个细胞都应该有