Chronic and prolonged, time-course impact of exercise on homeostatic appetite control

运动对稳态食欲控制的长期且长期的影响

• 批准号: RGPIN-2018-05091
• 负责人: Bomhof, Marc
• 金额: $ 1.75万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=645768
• 关键词: Chronic; prolonged; time; course; impact

As suggested by the phrase “you cannot outrun your fork”, it is generally understood that there is an increase in appetite and energy intake following exercise. Evidence for an ‘energy compensation' following exercise is supported by data showing minimal changes in body weight with long-term exercise. In contrast, substantial research demonstrates that exercise leads to acute reductions in appetite. Moreover, research investigating compensatory energy intake with exercise fails to show an increase in energy intake equaling exercise-induced energy expenditure. The precise reason for the discrepancy between reduced appetite and maintained body weight with exercise remains poorly understood. My research program aims to examine both the long-term and short-term impacts of exercise on appetite control. Using an animal model, my lab will assess the chronic, weight independent impacts of exercise training on appetite control signals. Furthermore, given the link between gut microbiota and gut-derived satiety hormones, my lab will examine whether exercise-induced changes in gut bacteria are associated with changes in appetite control signaling. With most exercise studies examining the changes in appetite that occur in the immediate post-exercise period, my research aims to assess the prolonged, time-course impacts of aerobic and resistance exercise on appetite-regulating hormones and energy intake using a series of studies in an animal model and human participants. Together, the proposed studies will help to increase our fundamental understanding of how exercise impacts the ‘energy intake' side of the energy balance equation. With a better understanding of how exercise affects appetite, this work will inform future research investigating strategies aimed at optimizing the metabolic benefits associated with exercise.

正如“你无法超越你的叉子”这句话所暗示的那样，人们普遍认为运动后食欲和能量摄入会增加。运动后“能量补偿”的证据有数据支持，数据显示长期运动体重变化很小。相反，大量研究表明运动会导致食欲急剧下降。此外，调查运动补偿性能量摄入的研究未能表明能量摄入的增加等于运动引起的能量消耗。运动后食欲下降与维持体重之间差异的确切原因仍知之甚少。 我的研究项目旨在研究运动对食欲控制的长期和短期影响。我的实验室将使用动物模型来评估运动训练对食欲控制信号的慢性、与体重无关的影响。此外，考虑到肠道微生物群和肠道来源的饱腹感激素之间的联系，我的实验室将研究运动引起的肠道细菌变化是否与食欲控制信号的变化有关。大多数运动研究都会检查运动后不久发生的食欲变化，我的研究旨在通过对动物模型和人类参与者进行一系列研究，评估有氧运动和抗阻运动对食欲调节激素和能量摄入的长期影响。总之，拟议的研究将有助于增强我们对运动如何影响能量平衡方程中“能量摄入”方面的基本理解。通过更好地了解运动如何影响食欲，这项工作将为未来研究旨在优化与运动相关的代谢益处的策略提供信息。