Prolonged Juvenile State and Juvenile Protective Factors Affect Chronic Diseases

长期青少年状态及青少年保护因素对慢性病的影响

• 批准号: 7778889
• 负责人: SHUMEI S SUN
• 金额: $ 28.75万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7778889
• 关键词: Adhesions; Adolescence; Adolescent; Adrenal Glands; Adult; Affect; Age; Aging; Androgens; Appearance; Biological Markers; Birth; Blood Vessels; Body Composition; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Cell Adhesion; Cell Adhesion Molecules; Childhood; Chronic Disease; Data; Dehydroepiandrosterone Sulfate; Development; Development Plans; Diagnosis; Diastolic blood pressure; Fasting; Fatty acid glycerol esters; Female; Freedom; Goals; Growth; Growth and Development function; Health; Height; Homeostasis; Insulin Resistance; Insulin-Like Growth Factor I; Joints; Leptin; Life; Link; Lipids; Longitudinal Studies; Measures; Menarche; Metabolic; Metabolic syndrome; Modeling; Natural History; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Physiological; Plasma; Population; Population Study; Prevalence; Protein C; Risk Factors; Testing; Time; Triglycerides; Weight Gain; Woman; adipokines; adiponectin; age group; bone age; boys; fasting plasma glucose; girls; inflammatory marker; male; men; prevent; protective effect; sex; sexual dimorphism; waist circumference

DESCRIPTION (provided by applicant): We will investigate factors involved in the rate of metabolic and cardiovascular aging in men and women in the Fels Longitudinal Study (FLS). Although it is possible to age in good health, in the U.S. population progressive weight gain (Yanovski et al 2000) and an increasing prevalence of the metabolic syndrome are common attributes of aging. The prevalence of adults in the FLS with BMI > 25kg/m2 increases from 30% in the fourth decade of life to 70% in the sixth decade, and the prevalence of the metabolic syndrome increase from 21% to 38% in men and from 14% to 34% in women the same age groups. Tempo of growth and development: We plan to ascertain the influence of a prolonged juvenile state, i.e., a retarded tempo of physiological development, on delaying the onset of the metabolic syndrome, cardiovascular disease (CVD), and type 2 diabetes mellitus (T2DM) later in life. To achieve this goal, we propose to link risk factors for these common but unhealthy features of aging to childhood tempo of physiological development. The tempo of physiological development will be determined in each subject by documenting his or her age at the time of the adiposity rebound; the onset of the pubertal growth spurt; the peak height velocity; menarche; and his or her bone age at each of these milestones. The temporal range of these milestones varies from 5 years for the adiposity rebound to nearly 8 years for menarche, and bone age may lag behind or jump ahead of chronological age by as much as 4.5 years in either direction. We plan to accomplish our objectives using long-term serial data collected from birth over periods as long as 75 years in 361 adult males and 354 adult females in the FLS. Juvenile protective factors: We also propose to examine levels of biomarkers measured in childhood and adolescence that are associated with a delayed onset of the metabolic syndrome, CVD, and T2DM. Such delays may be caused by the persistence of juvenile levels of protective factors into adulthood, or else by the persistence into adulthood of effects initiated by such factors in childhood. The biomarkers we will study include body composition, lipid profiles, adipokines, inflammatory markers, insulin resistance, insulin-like growth factor-1 (IGF-1), and adrenal androgens. We plan to identify which of these biomarkers measured during childhood and adolescence act to delay the onset of the metabolic syndrome, CVD, and T2DM and could be considered as juvenile protective factors. The proposed analysis of serial data collected over decades should reveal the natural history of the onset of the metabolic syndrome, CVD, and T2DM in relation to the tempo of growth and development during the first two decades of life and in relation to levels of biomarkers during childhood and adolescence that could be considered to be juvenile protective factors. We are examining features of childhood that prevent or delay the onset of unhealthy aspects of aging.

描述（由申请人提供）：我们将调查在FELS纵向研究（FLS）中，男性和女性代谢和心血管衰老率涉及的因素。 尽管有可能身体健康，但在美国人口的渐进式体重增加（Yanovski等，2000）和代谢综合征的越来越多的患病率是衰老的常见属性。 BMI> 25kg/m2的FL中成年人的患病率从生命的第四个十年中的30％增加到第六个十年的70％，而代谢综合征的患病率从男性的21％增加到38％，从男性的14％增加到34％的女性。 生长和发展的节奏：我们计划确定长期少年状态的影响，即生理发育的迟钝节奏，对延迟代谢综合征，心血管疾病（CVD）和2型糖尿病（T2DM）（T2DM）的延迟。 为了实现这一目标，我们建议将这些衰老的常见但不健康特征的风险因素与生理发展的儿童期节奏联系起来。 生理发展的速度将在每个学科中通过记录肥胖反弹时的年龄来确定。青春期生长的开始； 峰高速度； 初潮; 以及他或她的骨骼年龄在这些里程碑中。这些里程碑的时间范围从肥胖反弹的5年到初潮的近8年不等，骨龄可能会落后或以每年的年龄为单位偏向4.5岁。 我们计划在361名成年男性和354名成年女性中，使用从出生开始的长期序列数据来实现我们的目标。 青少年保护因素：我们还建议检查儿童和青春期测得的生物标志物水平，这些水平与代谢综合征，CVD和T2DM的延迟发作有关。 这样的延迟可能是由于少年水平的保护因素持续存在，或者是由于这些因素在儿童时期引发的效应的持续存在。 我们将研究的生物标志物包括身体成分，脂质谱，脂肪因子，炎症标记，胰岛素抵抗，胰岛素样生长因子1（IGF-1）和肾上腺雄激素。 我们计划确定在儿童期和青春期中测量哪些生物标志物，以延迟代谢综合征，CVD和T2DM的发作，并被视为少年保护因素。 对数十年来收集的序列数据的拟议分析应揭示代谢综合征，CVD和T2DM发作的自然历史，该生命的最初二十年中的生长和发育速度与生命的前二十年有关，并且与童年和青少年期间的生物标志物水平有关，这可以被认为是少年保护因素。我们正在研究童年的特征，这些特征可以预防或延迟衰老不健康方面的发作。