Measurement of streaming potential for determination of capillary surface characteristics

测量流动电位以确定毛细管表面特性

• 批准号: 531138-2018
• 负责人: Chen, David
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=647320
• 关键词: Measurement; streaming; potential; determination; capillary

The proposed project aims to use a new capillary electrophoresis instrument manufactured in the local area to**characterize the surface properties of capillaries coated with various coating materials. Capillary**electrophoresis has become one of the most important analytical separation techniques used in the analysis of**biopharmaceutical industry, biomedical research, and industrial manufacturing activities. Reproducibility of**chemical analysis is essential for all analytical methods. Maintaining a chemically clean surface for the**capillary used in CE in one of the critical conditions for obtaining reproducible migration times. The applicant**will develop strategies and methods to evaluate the relationship between the streaming potential with different**capillary surface conditions, different buffer systems, and different covalent and non-covalent surface coatings.**The results will provide important guidance for researchers and other instrument users in their method**development to generate high quality and reproducible results.

拟议项目旨在使用当地生产的新型毛细管电泳仪，** 表征涂有各种涂层材料的毛细管的表面特性。毛细管电泳已成为生物制药、生物医学研究和工业生产活动中最重要的分析分离技术之一。** 化学分析的重现性对所有分析方法都是必不可少的。在获得可重现迁移时间的关键条件之一中，保持CE中使用的 ** 毛细管的化学清洁表面。申请人 ** 将开发策略和方法，以评估流动电位与不同 ** 毛细管表面条件、不同缓冲系统以及不同共价和非共价表面涂层之间的关系。**这些结果将为研究人员和其他仪器用户的方法 ** 开发提供重要指导，以产生高质量和可重复的结果。