Design of a bracelet embedding high-frequency ultrasound transducers to acquire venous blood echogenicity spectral data for patient monitoring

每天，住进重症监护病房的患者都在经历并发症，而且往往**致命的病情恶化。严重的并发症导致多器官功能障碍综合征或MODS，死亡率为41%。MODS的特点是严重的急性炎症反应，导致血管血栓形成、感染性休克和器官和组织的氧合受损。可以开炎性血液标记物**用于患者监测，但结果要在采样几小时或几天后才能得到。在需要迅速做出医疗决定以提高患者存活率的情况下，这些血液测试往往没有价值。在这项赠款申请中，我们提出了一种新的床边**超声波技术来持续监测炎症状态，以实现最佳的患者**治疗。**红细胞(RBC)聚集是炎症的一个强有力的标志，并具有通过超声波成像提供持续监测能力的独特**优势。这项拨款**建议开发和集成技术，以基于高频超声频谱数据的分析来提供护理点患者**监测，以测量**流动在手臂或脚踝浅静脉内的红细胞的**随时间变化的聚集。**猪模型的临床前结果证实了监测炎症的能力，并利用超声波促进了**红细胞的聚集。提出的算法获得了专利，我们**建议开发一种便携式仪器，用于限制区域**手术室和重症监护病房。该仪器将包括一个戴在患者身上的手镯和嵌入的高频超声换能器，一个用于**控制血流的闭塞设备，以及一个用于收集由**微型计算机仪器处理的超声数据的定位设备，以向临床医生提供关于红细胞聚集状态的反馈。

Every day, patients admitted to critical care units are experiencing complications and often**fatal deteriorating conditions. Severe complications leading to the syndrome of multiple organ**dysfunctions or MODS result in a mortality rate at 41%. The MODS condition is characterized**by a severe acute inflammatory reaction leading to vascular thrombosis, septic shock and**impaired oxygenation of organs and tissues. Inflammatory blood markers can be prescribed**for patient monitoring but results are obtained hours or days after sampling. In conditions**where rapid medical decisions are required to improve the likelihood of patient survival, those**blood tests are often of no value. We propose in this grant application a new bed side**ultrasound technology to continuously monitor the state of inflammation for optimum patient**treatment.**Red blood cell (RBC) aggregation is a strong marker of inflammation and has the unique**advantage of offering continuous monitoring capability through ultrasound imaging. This grant**proposes the development and integration of technologies to provide point-of-care patient**monitoring based on the analysis of high-frequency ultrasound spectral data to measure the**time-varying clustering of RBCs flowing within a superficial vein of the arm or ankle.**Preclinical results in a porcine model confirmed the capability of monitoring inflammationpromoted**aggregation of RBCs with ultrasound. The proposed algorithm is patented and we**propose the development of a portable instrument for use in restricted areas as surgery**rooms and intensive care units. This instrument will consist in a bracelet attached innocuously**to the patient and embedding high-frequency ultrasound transducers, an occluding device to**control the blood flow, and a positioning device to collect ultrasound data processed by a**miniaturized computer instrument to provide feedback to clinicians on the state of RBC**aggregation.