Solutions for the Efficient Scale-Up of Pharmaceuticals Prepared via Photocatalysis**

通过光催化制备的药物有效放大的解决方案**

• 批准号: 534387-2018
• 负责人: Collins, Shawn
• 金额: $ 1.82万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=647944
• 关键词: Solutions; Efficient; Scale; Up; Pharmaceuticals

Synthetic chemistry is a critical component of modern chemical manufacturing that affords society everything from medicines, cosmetics, textiles and materials. The design of synthetic chemical routes for large scale production is shifting away from batch processes to continuous flow processes, which offer several advantages that are highly sought after by industrial partners including facile scale-up, increased safety, energy efficiency and decreased waste produced. The current proposal involves the development of new photochemical processes that are of interest to drug development efforts of Intellisyn. Consequently, investigation of continuous flow alternatives to render those processes practical for scale-up will be evaluated. These studies would translate into improved synthesis processes, and accelerate the development and manufacture of specialty chemicals related to the drug discovery, development or pharmaceutical industries in general. This would result in direct benefits for the technology sector of Canada and contribute to the continued growth of the chemical industry within Canada, leading to overall boosts in the economy.**

合成化学是现代化学制造的关键组成部分，它为社会提供了从药品、化妆品、纺织品到材料的一切。用于大规模生产的合成化学路线的设计正在从间歇过程转向连续流动过程，这些过程提供了几个备受工业合作伙伴追捧的优势，包括易于扩大规模、提高安全性、能源效率和减少产生的废物。目前的提案涉及开发对Intelliyn的药物开发工作感兴趣的新的光化学过程。因此，将对连续流动替代品的研究进行评估，以使这些工艺适用于扩大规模。这些研究将转化为改进的合成工艺，并加快与药物发现、开发或制药行业相关的特种化学品的开发和制造。这将为加拿大的技术部门带来直接利益，并有助于加拿大国内化学工业的持续增长，从而促进经济的全面发展。**