Deciphering the Arabidopsis NPR1-dependent disease-resistance signal transduction pathway and beyond.

破译拟南芥 NPR1 依赖性抗病信号转导途径及其他途径。

• 批准号: RGPIN-2017-04065
• 负责人: Després, Charles
• 金额: $ 1.89万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=649117
• 关键词: Deciphering; Arabidopsis; NPR1; dependent; disease

Plants provide us with the food and oxygen we require for our survival. This dependence on plants for food production translates into agriculture being a major employer in Canada. Nevertheless, farm income is dependent on productivity and one of the major problems curtailing agricultural yield is disease caused by microorganisms called pathogens. To protect crops, farmers spray their fields with pesticides, which are chemicals designed to kill pathogens. As a complementary line of defense in crop protection is the use of varieties with enhanced disease resistance to pathogens. The development of these varieties has traditionally been the area of focus of plant breeders. However, molecular biologists and biochemists bring another dimension to this quest. Accordingly, they can develop molecular markers useful in assisting breeders to select resistant varieties. At the same time, molecular biologists and biochemists focus on developing long-term solutions, which require a thorough understanding of the molecular events leading to pathogen resistance. One of these solution is to develop chemistries designed to stimulate a crop's own immune system, similar conceptually to the way a vaccine boost a person's immune system.*******In that line of thought, the goal of the proposed research program is to generate new knowledge that will bring us one step closer to unraveling the black box that holds the molecular events leading to pathogen resistance. This goal will be accomplished by studying the arabidopsis NPR1 pathway and the proteins that control this disease resistance system. The new knowledge generated in this proposal will be from modern multidisciplinary tools including molecular biology, biochemistry, genetics, genomics and bioinformatics. The outcomes produced will, in time, lead to the development of durable and environmentally friendly disease resistance in crops, which will be an economic asset for Canadian farmers and an environmental benefit for all Canadians.***

植物为我们提供生存所需的食物和氧气。这种对植物生产粮食的依赖使农业成为加拿大的主要雇主。然而，农业收入取决于生产力，而限制农业产量的主要问题之一是由称为病原体的微生物引起的疾病。为了保护农作物，农民们用杀虫剂喷洒他们的田地，杀虫剂是一种旨在杀死病原体的化学物质。作为作物保护的补充防线，使用对病原体具有增强抗病性的品种。这些品种的开发历来是植物育种家的重点领域。然而，分子生物学家和生物化学家为这一探索带来了另一个维度。因此，他们可以开发出有助于育种者选择抗性品种的分子标记。与此同时，分子生物学家和生物化学家专注于开发长期解决方案，这需要彻底了解导致病原体抗性的分子事件。这些解决方案之一是开发旨在刺激作物自身免疫系统的化学物质，在概念上类似于疫苗增强人体免疫系统的方式。按照这种思路，拟议的研究计划的目标是产生新的知识，使我们更接近解开黑匣子，其中包含导致病原体耐药性的分子事件。这一目标将通过研究拟南芥NPR1途径和控制这种抗病系统的蛋白质来实现。本提案产生的新知识将来自现代多学科工具，包括分子生物学、生物化学、遗传学、基因组学和生物信息学。所产生的成果将及时导致作物持久和环境友好的抗病性的发展，这将是加拿大农民的经济资产，也是所有加拿大人的环境利益。