Using a novel androgen receptor knock-in mouse model to investigate defects in circadian rhythm linked to the development Metabolic Syndrome.

使用新型雄激素受体敲入小鼠模型来研究与代谢综合征的发展相关的昼夜节律缺陷。

• 批准号: 390316
• 负责人: Trifiro Mark A
• 金额: $ 56.29万
• 依托单位: Lady Davis Institute for Medical Research (Mtl)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=390316&lang=en
• 关键词: Androgen Receptor; Circadian Rhythm; Clock Genes; Fatty Liver Disease; Mouse Model; Nash

Metabolic syndrome (MetS) comprises a collection of disorders that include obesity, type 2 diabetes, hypertension, lipid disorders and liver diseases. The health implications of metabolic syndrome are enormous as each disorder mentioned above has signific

代谢综合征（MetS）包括一系列疾病，包括肥胖症、2型糖尿病、高血压、脂质紊乱和肝病。代谢综合征对健康的影响是巨大的，因为上述每种疾病都有显著的