CRISPR-GWAS: Leveraging genome-editing to identify disease-causing genes

CRISPR-GWAS：利用基因组编辑来识别致病基因

• 批准号: 392290
• 负责人: Morris John A
• 金额: $ 10.2万
• 依托单位: New York Genome Center (New York, NY)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-09-01 至 2020-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=392290&lang=en
• 关键词: Blood Genetics; Causal Snps; Crispr; Epigenomics; Fine-Mapping; Functional Genomics; Genome-Editing; Genome-Wide Association Study; Non-Coding Genome; Xcas9

The discovery of disease-causing genes is crucial to understand how diseases function and to design new drug targets. Over the past decade, researchers have performed large genetic studies, looking at DNA base pair differences that commonly occur in the p

致病基因的发现对于了解疾病的功能和设计新的药物靶点至关重要。在过去的十年里，研究人员进行了大规模的基因研究，观察了在人类基因组中常见的dna碱基对差异。