Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies

神经退行性疾病的功能基因组学：定义生物标志物和个性化治疗的分子发病机制和靶点

• 批准号: 387968
• 负责人: St. George-Hyslop Peter H
• 金额: $ 223.13万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-09-01 至 2025-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=387968&lang=en
• 关键词: Alzheimer Disease; Biomarkers; Frontotemporal Lobar Degeneration; Functional Genetics Of Risk Genes; Intrinsically Disordered Phase Separating Proteins; Neurological Disorders; Therapeutic Targets

Neurodegenerative dementias are the fourth leading cause of death worldwide, affecting >24 million people at a cost of >US$172 billion annually. Despite a lot of effort, apart from a handful of mildly effective symptomatic treatments there are no proven w

神经退行性痴呆是全球第四大死亡原因，每年影响超过2400万人，成本超过1720亿美元。尽管做了大量的努力，除了少数温和有效的对症治疗外，还没有被证明是有效的。