The role in Abeta synaptotoxicity of kinases identified through functional and genetic studies in Alzheimer Disease
The role in Abeta synaptotoxicity of kinases identified through functional and genetic studies in Alzheimer Disease
批准号:
234243
负责人:
St. George-Hyslop Peter H
金额:
$72.75万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-05-01 至 2015-05-01
中文摘要
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英文摘要
The accumulation of Abeta peptides in the form of neurotoxic soluble aggregates is a key molecular and neuropathological feature of Alzheimer's disease (AD). Changes in synaptic plasticity mediated by the neurotoxic effects of these soluble oligomeric ass
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会议论文
Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies
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批准号:387968
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项目类别:Operating Grants
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资助金额:$223.13万
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财政年份:2018
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负责人:St. George-Hyslop Peter H
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依托单位:
Mutational and Functional Analysis of Genes Identified by GWAS Studies of Alzheimer's Disease
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批准号:224964
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项目类别:Operating Grants
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资助金额:$107.32万
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财政年份:2011
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负责人:St. George-Hyslop Peter H
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依托单位:
国内基金
海外基金
骨髓基质干细胞移植对AD(Alzheimer disease)小鼠海马及额叶神经细胞死亡干预的实验研究
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批准号:81301089
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项目类别:青年科学基金项目
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资助金额:23.0万元
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批准年份:2013
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负责人:商敬伟
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依托单位: