Synthetic Biology

合成生物学

• 批准号: CRC-2017-00034
• 负责人: Kachroo, Aashiq
• 金额: $ 8.74万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=654961
• 关键词: Synthetic; Biology

The remarkable extent to which the protein-coding genes are still functionally equivalent between *humans and yeast emphasizes the power of distant organisms for studying human processes. *Humans and yeast obviously differ dramatically with respect to cell and tissue organization. *Nonetheless, our recent systematic study showed that nearly half of the tested protein-coding *human genes could substitute for their yeast equivalents. The results reveal which conserved *processes are still interchangeable creating direct assays of human gene function for that subset. *Finally, these studies demonstrate the broad equivalence of function between yeast and humans, *providing fundamental insights into gene evolution.

人类和酵母菌之间的蛋白质编码基因在功能上仍然相当的惊人程度，突显了遥远生物在研究人类过程方面的力量。*人类和酵母在细胞和组织组织方面明显不同。尽管如此，我们最近的系统研究表明，近一半测试的蛋白质编码*人类基因可以取代它们的酵母等效物。结果揭示了哪些保守的过程仍然可以互换，从而为该子集创造了直接的人类基因功能分析。*最后，这些研究证明了酵母和人类在功能上的广泛等价性，*为基因进化提供了基本的见解。