Measuring and modelling the mechanical and failure behaviour of bone

测量和模拟骨骼的机械和失效行为

• 批准号: RGPIN-2015-05109
• 负责人: Lievers, William
• 金额: $ 1.6万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=657614
• 关键词: Measuring; modelling; mechanical; failure; behaviour

The health and safety of Canadians is a fundamental priority.  Its societal importance is underscored by the Canadian government's decision to identify "health and related life sciences and technologies" as one of the four priority areas for federal research funding.   Since the skeleton plays such an important structural and protective role, the proposed research program would contribute to these federal objectives by improving our ability to measure and model the mechanical and failure behaviour of bone.  ***Within this long-term objective, two specific lines of research would be investigated.   The first would consider the structural effects of cancellous bone.  Also referred to as trabecular or spongy bone, cancellous bone is a network of bony plates and struts (referred to as trabeculae) located primarily in the ends of long bones or within vertebrae.  Both the amount and the arrangement of cancellous bone -referred to as the "architecture"- change as a function of age or disease such as osteoporosis.   These changes increase a person's susceptibility to bone fracture.  High-resolution three-dimension images of cancellous bone will be used to create numerical models capable of illuminating the important relationship between architecture and mechanical integrity.  Improving our understanding in this area will allow the medical community to more accurately measure the mechanical integrity of bone, which is critical for monitoring and assessing someone's risk of suffering an age- or disease-related fracture.****The second line of research would investigate the response of bone to sharp-force trauma.  Forensic investigators and the medicolegal community routinely use tool marks and bone fracture surfaces to estimate the amount of force required to create an injury.   To date, this information is qualitative.   A new experimental device for simulating repeatable, instrumented sharp-force impacts is currently being developed at Laurentian University.   By performing simulated impacts, under prescribed conditions, this research will provide forensic investigators with a more rigorous methodology for determining quantitative estimates of impact force.  Specifically, numerical models will be developed to relate the rate and force of an impact to the resulting injury patterns.   This research will both improve our fundamental understanding of the rate-dependent failure mechanisms of cortical bone and provide a powerful investigative tool.******This multi-pronged approach will deepen our knowledge of the mechanical and failure behaviour of bone, as well as improve our ability to model and predict these behaviours.   The transfer of this knowledge to the medical, medicolegal, and other communities, will allow this information to be applied to improve the health and safety of Canadians.**

加拿大人的健康和安全是一个基本的优先事项。 加拿大政府决定将“健康及相关生命科学和技术”确定为联邦研究资助的四个优先领域之一，这突出了其社会重要性。 由于骨骼起着如此重要的结构和保护作用，拟议的研究计划将有助于这些联邦的目标，提高我们的能力，测量和模拟骨的机械和故障行为。 * 在这一长期目标范围内，将调查两个具体的研究方向。 第一种是考虑松质骨的结构效应。 松质骨也称为骨小梁或松质骨，是主要位于长骨末端或椎骨内的骨板和支柱（称为骨小梁）的网络。 松质骨的数量和排列-称为“结构”-随着年龄或疾病（如骨质疏松症）的变化而变化。 这些变化增加了一个人对骨折的易感性。 松质骨的高分辨率三维图像将用于创建能够阐明结构和机械完整性之间的重要关系的数值模型。 提高我们在这一领域的理解将使医学界能够更准确地测量骨骼的机械完整性，这对于监测和评估某人遭受年龄或疾病相关骨折的风险至关重要。第二个研究方向是研究骨骼对锐器创伤的反应。 法医调查人员和法医界通常使用工具痕迹和骨折表面来估计造成伤害所需的力量。 迄今为止，这一信息是定性的。 目前，劳伦特大学正在开发一种新的实验装置，用于模拟可重复的、装有仪器的锐利力撞击。 通过在规定条件下进行模拟撞击，这项研究将为法医调查人员提供更严格的方法来确定撞击力的定量估计。 具体而言，将建立数字模型，将撞击的速度和力量与造成的伤害模式联系起来。 这项研究将提高我们对皮质骨的速率依赖性失效机制的基本理解，并提供一个强大的研究工具。这种多管齐下的方法将加深我们对骨的机械和失效行为的了解，并提高我们建模和预测这些行为的能力。 将这些知识转移到医学，法医学和其他社区，将使这些信息能够应用于改善加拿大人的健康和安全。