FUNDAMENTALS AND APPLICATIONS OF PLASMONICS AND ULTRAFAST LASERS IN THERANOSTIC NANOMEDECINE

等离激元和超快激光在治疗纳米医学中的基础知识和应用

• 批准号: RGPIN-2018-05288
• 负责人: Meunier, Michel
• 金额: $ 2.99万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=659693
• 关键词: FUNDAMENTALS; APPLICATIONS; PLASMONICS; ULTRAFAST; LASERS

Nanomedicine, the branch of nanotechnology dealing with bringing applications to the medical world, seeks to deliver a valuable set of research biomedical tools and clinically useful devices and approaches, such as nano-optical biosensors and targeted therapy. It is anticipated that nanomedecine will also find its applications in the new developing theranostics approaches, a proposed process involving combined therapy and diagnostic for individual patients. The proposed research program specifically deals with the applications of optics to nanomedecine, mostly emphasising the physics and engineering developments. Two interrelated approaches and tools involving plasmonics and ultrashort pulses will be developed. Bioplasmonics exploits the optical properties of metallic nanostructures at the nanoscale and can be used to either detect very low concentrations of analytes, image specific cells or organs or transmit locally energy for therapeutic purposes. Due to its ultrashort pulses, the use of femtosecond lasers offers new ways to interact with materials, nanomaterials and biological media and opens up innovative approaches to biodetection, imaging, surgery and therapy. The aim of the proposed research program is to develop and model new plasmonic nanostructures and ultrafast laser nanoprocesses for theranostic biomedical applications, such as biosensing, hyperspectral imaging, cell transfection, cancer therapy, eye surgery, gene therapy and neuron stimulation with the long term objective to introduce new devices and approaches for nanomedecine applications, such as imaging, biodetection and therapy. Over the five year period, the Discovery research program will contribute to the training of 10 undergraduate students, 4 masters, 5 PhDs, 2 Postdoctoral fellows, and one part time technician. These highly qualify personnels will be trained in nanotechnologies and laser technologies for various applications in nanomedecine which are highly relevant to many Canadian biomedical industries, research centers, universities and hospitals. In summary, this research will bring new basic knowledge, materials and technologies for imaging, biodetection and therapy for the expanding important field of nanomedecine and theranostics. We anticipate that the findings and developed technologies will improve Canadian's quality of life and could potentially save lives.

纳米医学是纳米技术的分支，致力于将其应用于医学领域，旨在提供一套有价值的研究生物医学工具和临床有用的设备和方法，如纳米光学生物传感器和靶向治疗。预计nanomedecine也将在新开发的治疗诊断方法中找到其应用，这是一种涉及个体患者联合治疗和诊断的拟议过程。拟议的研究计划专门涉及光学在纳米医学中的应用，主要强调物理和工程发展。将开发涉及等离子体激元和超短脉冲的两种相互关联的方法和工具。生物等离子体利用纳米级金属纳米结构的光学特性，可用于检测非常低浓度的分析物，对特定细胞或器官进行成像，或为治疗目的传输局部能量。由于其超短脉冲，飞秒激光的使用提供了与材料，纳米材料和生物介质相互作用的新方法，并为生物检测，成像，手术和治疗开辟了创新方法。拟议的研究计划的目的是开发和模拟新的等离子体纳米结构和超快激光纳米过程的治疗诊断生物医学应用，如生物传感，高光谱成像，细胞转染，癌症治疗，眼科手术，基因治疗和神经元刺激的长期目标，以引入新的设备和方法nanomedecine应用，如成像，生物检测和治疗。在五年的时间里，发现研究计划将有助于培养10名本科生，4名硕士，5名博士，2名博士后研究员和一名兼职技术人员。这些高素质的人员将接受纳米技术和激光技术的培训，用于纳米医学的各种应用，这些应用与许多加拿大生物医学行业，研究中心，大学和医院高度相关。总之，这项研究将为纳米医学和治疗诊断学这一日益扩大的重要领域带来新的成像、生物检测和治疗的基础知识、材料和技术。我们预计，这些发现和开发的技术将提高加拿大人的生活质量，并可能挽救生命。