Development and mechanisms of stress resiliency.

压力恢复能力的发展和机制。

• 批准号: RGPIN-2014-04348
• 负责人: Perrot, Tara
• 金额: $ 2.19万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=661999
• 关键词: Development; mechanisms; stress; resiliency.

Behavioural and/or physiological responses to stressors enable an organism to deal effectively with the challenge, and regain homeostasis. While necessary, the stress response can lead to various deleterious effects in certain individuals. However, such effects are not observed in all individuals that are exposed to stress, or even extreme trauma, so, while it is important to uncover the mechanisms underlying vulnerability to the effects of stress, it is equally valid to pose the question - `what are the mechanisms at work in individuals that are resilient in the face of stress?' In the face of a changing environment, a variable coping strategy will be most effective for establishing an individual as being resilient, versus being vulnerable, to stress. We will examine the underlying mechanisms of coping and resilience using animal models. We will build on our past work and investigate the influence of key factors in the early and adolescent environment (parents, social structure) with respect to building coping behaviours in adulthood. We will also examine the underlying neural mechanisms. This work will provide information that could lead to interventions that move individuals toward the resilient end of the susceptibility-resilient continuum.

对压力源的行为和/或生理反应使生物体能够有效地应对挑战，并恢复稳态。虽然必要，但压力反应可能导致某些个体的各种有害影响。然而，并非所有遭受压力甚至极端创伤的人都能观察到这种影响，因此，虽然揭示易受压力影响的潜在机制很重要，但提出这样的问题也同样有效--“是什么”在面对压力时具有弹性的个人中发挥作用的机制？“面对不断变化的环境，一个可变的应对策略将是最有效的建立一个人的弹性，而不是脆弱的，压力。我们将使用动物模型来研究应对和复原力的潜在机制。我们将在过去工作的基础上，调查早期和青少年环境（父母、社会结构）中的关键因素对成年后建立应对行为的影响。我们还将研究潜在的神经机制。这项工作将提供信息，可能导致干预措施，使个人走向韧性-韧性连续体的韧性端。