Fundamental Biobehavioral Mechanisms Underlying the Integrated Development of Emotion, Attachment, and Nutritive Intake in the Mother-Infant Dyad

母婴二元情感、依恋和营养摄入综合发展的基本生物行为机制

• 批准号: 10583348
• 负责人: Julie C Lumeng
• 金额: $ 75.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583348
• 关键词: 3 year old; Adult; Affective; Behavior; Biology; Birth; Child; Childhood; Compensation; Cues; Development; Dietary intake; Distress; Eating; Eating Behavior; Emotional; Emotions; Exposure to; Face; Feeding behaviors; Food; Future; Goals; Growth; Heart Rate; Hunger; Hydrocortisone; Hyperphagia; Infant; Intake; Learning; Life; Link; Literature; Longevity; Methods; Milk; Modeling; Mothers; Obesity; Opioid; Oxytocin; Physiology; Randomized, Controlled Trials; Reporting; Research; Rewards; Risk Factors; Satiation; Social Environment; Social Interaction; Stimulus; Stress; Sucrose; System; Systems Integration; Testing; Weight Gain; Work; behavioral response; biobehavior; caregiving; cohort; eating in absence of hunger; feeding; hedonic; infancy; infant adiposity; maternal caregiving; novel; nutrition; obesity in children; pain relief; predicting response; preference; response; stressor; theories; therapy development; willingness

PROJECT SUMMARY The rate of weight gain in the first year of life is a robust risk factor for future obesity. The use of food to soothe has been linked to greater weight gain and has been theorized to contribute to future reward-driven or emotional overeating. However, avoiding the use of food to soothe is challenging for mothers, particularly for children who are less easily soothed by other strategies. Conceptual models to date have viewed infant distress due to hunger as distinct from infant distress due to other causes. These models encourage a separation of food as nutrition from food as soothing. However, diverse literatures converge to suggest that emotion, mother-infant attachment, maternal feeding, and infant eating behavior are appropriately intertwined and co-develop in adaptive ways. This proposal seeks to test an entirely novel comprehensive model of bidirectional biobehavioral mechanisms underlying the development of an integrated system of emotion, attachment, and nutritive intake in the mother-infant dyad across birth, 3 months, and 6 months. Further, we propose to test the association of this system with maternal feeding behavior, child eating behavior, dietary intake, and adiposity to age 3 years. Using novel experimental methods in a cohort of 120 children, we will address the following aims: Aim 1: To test the cross-lagged associations of maternal-infant dyadic stress physiology and maternal-infant dyadic oxytocin physiology with feeding to soothe and infant adiposity. H1a: Greater maternal and infant cortisol response and heart rate elevation in response to an infant stressor predicts more use of feeding to soothe and greater infant adiposity. H1b: Lower maternal and infant oxytocin response to caregiving predicts greater use of feeding to soothe, and greater infant adiposity. Aim 2: To test the cross-lagged associations of sucrose effects on infant opioid physiology with feeding to soothe and infant adiposity. H2: Behavioral response to sucrose characterized by greater relief of pain, greater relief of distress, and greater hedonic response predicts greater use of feeding to soothe and greater infant adiposity. Aim 3: To test the cross-lagged associations of the potency of maternal social interaction effects on infant eating with feeding to soothe and infant adiposity. H3: Greater effect of social interaction on increasing infant willingness to work for food, reducing capacity for caloric compensation, and relieving distress following a feeding delay predicts greater use of feeding to soothe and greater infant adiposity. Aim 4: To test the association of the ‘emotion-attachment- nutritive intake-system’ in infancy with maternal feeding behavior, child eating behavior, child dietary intake, and child adiposity at age 3 years. H4: Greater maternal-infant dyadic stress physiology, lower maternal-infant dyadic oxytocin physiology, greater sucrose effects on infant opioid physiology, and greater potency of maternal social interaction effects on eating in infancy predicts greater indulgent feeding, eating in the absence of hunger, overeating following caloric preload, reinforcing value of food, affective response to food delay, dietary intake of sweets, and adiposity at age 3 years.

项目摘要 出生后第一年的体重增加率是未来肥胖的一个强有力的风险因素。用食物来抚慰 与更大的体重增加有关，并且理论上有助于未来的奖励驱动或 情绪化暴饮暴食然而，避免使用食物来抚慰对母亲来说是一个挑战，特别是对于 那些不太容易被其他策略安抚的孩子。迄今为止，概念模型已经将婴儿 由于饥饿而引起的痛苦，与其他原因引起的婴儿痛苦不同。这些模式鼓励 把食物从营养和安慰中分离出来。然而，不同的文献都表明， 情感、母婴依恋、孕产妇喂养和婴儿饮食行为适当地交织在一起 并以适应性的方式共同发展。该提案旨在测试一种全新的综合模型， 双向生物行为机制是情感综合系统发展的基础， 依恋和营养摄入的母亲-婴儿二人在出生时，3个月，6个月。我们还 建议测试该系统与母亲喂养行为，儿童饮食行为，饮食 摄入量和肥胖到3岁。在120名儿童的队列中使用新的实验方法，我们将 目的1：检验母婴二元压力的交叉滞后关系 生理学和母婴二元催产素生理学与喂养安抚和婴儿肥胖症。H1a： 对婴儿应激源的更大的母婴皮质醇反应和心率升高 预测更多使用喂养来安抚和更大的婴儿肥胖。H1b：降低母婴催产素 对喂奶的反应预示着更多地使用喂养来抚慰，以及更多的婴儿肥胖。目标2：测试 蔗糖对婴儿阿片生理学影响的交叉滞后关联与喂养安慰和婴儿 肥胖症H2：对蔗糖的行为反应，其特征在于更大程度地缓解疼痛，更大程度地缓解痛苦， 更大的享乐反应预示着更多地使用喂养来安抚和更大的婴儿肥胖。目标3： 测试母亲社会互动对婴儿饮食影响的交叉滞后关联， 喂养安抚和婴儿肥胖症。H3：社会互动对增加婴儿意愿的影响更大 为食物而工作，降低热量补偿能力，缓解进食延迟后的痛苦 预测更多地使用喂养来安抚和更多的婴儿肥胖。目的4：测试 婴儿期“情感-依恋-营养摄入系统”与母亲喂养行为、儿童进食行为、 儿童膳食摄入量和3岁儿童肥胖率。H4：更大的母婴二元应激生理学， 较低的母婴二元催产素生理学，对婴儿阿片样物质生理学的较大蔗糖效应，以及 母亲的社会互动对婴儿期进食的影响力越大，预示着婴儿期的喂养越放纵， 在没有饥饿的情况下进食，在热量预负荷后暴饮暴食，强化食物的价值，情感 3岁时对食物延迟、甜食摄入和肥胖的反应。