Role of the cell membrane calcium channel TRPV6 on physiological and metabolic functions.

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In cells having an important structural role of some organs, a protein participating in the regulation of calcium,**TRPV6, has been shown to be involved in the establishment of a microenvironment that favors tumour**development. However, little is known about the functional role and mechanism of this recently found protein.**This project will adress the role of this calcium-dependent channel protein, how it helps the cells to regulate**calcium concentration, and how it affects the immune system. Specifically, we will investigate the pathways**involved in the communication of TRPV6-expressing cells with immune cells. For this purpose, we will select**cells from multiple types of tissues, verify their TRPV6 expression, and the immune sytem signalling**molecules (cytokines/chemokines expression). The cells with the highest TRPV6 expression will then be**treated with inhibitors that have been designed by the participating company (Soricimed), and changes in the**immune communication between cells will be evaluated. Moreover, the physiology and metabolism of these**cells will also be determined to control for any other side effects. This initial project will allow Soricimed to**shed light on the fundamental mechanisms determining TRPV6 expression and function. Moreover, it will be a**stepping stone for the screening of therapeutic tools that will have a greater chance of success in the clinic and**to invest in performing follow-up proof of concept studies.