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Role of the cell membrane calcium channel TRPV6 on physiological and metabolic functions.

细胞膜钙通道TRPV6对生理和代谢功能的作用。

基本信息

批准号：
528340-2018
负责人：
Pichaud, Nicolas
金额：
$ 1.82万
依托单位：
Université de Moncton
依托单位国家：
加拿大
项目类别：
Engage Grants Program
财政年份：
2018
资助国家：
加拿大
起止时间：
2018-01-01 至 2019-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=662119
关键词：
Role cell membrane calcium channel

项目摘要

In cells having an important structural role of some organs, a protein participating in the regulation of calcium,**TRPV6, has been shown to be involved in the establishment of a microenvironment that favors tumour**development. However, little is known about the functional role and mechanism of this recently found protein.**This project will adress the role of this calcium-dependent channel protein, how it helps the cells to regulate**calcium concentration, and how it affects the immune system. Specifically, we will investigate the pathways**involved in the communication of TRPV6-expressing cells with immune cells. For this purpose, we will select**cells from multiple types of tissues, verify their TRPV6 expression, and the immune sytem signalling**molecules (cytokines/chemokines expression). The cells with the highest TRPV6 expression will then be**treated with inhibitors that have been designed by the participating company (Soricimed), and changes in the**immune communication between cells will be evaluated. Moreover, the physiology and metabolism of these**cells will also be determined to control for any other side effects. This initial project will allow Soricimed to**shed light on the fundamental mechanisms determining TRPV6 expression and function. Moreover, it will be a**stepping stone for the screening of therapeutic tools that will have a greater chance of success in the clinic and**to invest in performing follow-up proof of concept studies.

在对某些器官具有重要结构作用的细胞中，参与钙调节的蛋白质 ** TRPV 6已被证明参与建立有利于肿瘤 ** 发展的微环境。然而，关于这种最近发现的蛋白质的功能作用和机制知之甚少。该项目将讨论这种钙依赖性通道蛋白的作用，它如何帮助细胞调节钙浓度，以及它如何影响免疫系统。具体来说，我们将研究参与TRPV 6表达细胞与免疫细胞通讯的途径。为此，我们将从多种类型的组织中选择 ** 细胞，验证它们的TRPV 6表达和免疫系统信号传导 ** 分子（细胞因子/趋化因子表达）。然后，具有最高TRPV 6表达的细胞将用参与公司（Soricimed）设计的抑制剂进行 ** 处理，并评估细胞之间 ** 免疫通讯的变化。此外，还将确定这些 ** 细胞的生理和代谢，以控制任何其他副作用。这个初始项目将使Soricimed能够阐明决定TRPV 6表达和功能的基本机制。此外，它将成为筛选治疗工具的垫脚石，这些工具将有更大的机会在临床上取得成功，并投资于进行后续的概念验证研究。