Quantifying the drivers of animal migration
量化动物迁徙的驱动因素
基本信息
- 批准号:RGPIN-2017-03934
- 负责人:
- 金额:$ 2.11万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Migration is a complex behaviour that evolved independently and repeatedly across the animal kingdom and is vitally important in shaping population dynamics and ecosystem processes. However, migration events have started to disappear primarily due to climate change and other anthropogenic factors. This has led to an urgency to understand the internal drivers of migration, with an emphasis on genomic architecture and physiological mechanisms. The goal of such assessments is to evaluate whether populations can cope with anthropogenic and environmental changes to their migratory routes.******Numerous adaptations are required for migration and clear patterns of inheritance and a genetic underpinning have been demonstrated. My DG program aims to undercover the drivers of migration by focussing on a unique suite of ungulates (moose, mule deer, and mountain goat) that exhibit a range of migratory behaviour. The feasibility of my program is reflected in already having multi-year GPS tracking data and frozen tissue. The GPS location data will be used to determine individual migration patterns (timing, destination, and habitat selection) that will be quantitatively linked to genomic and physiological variation. ******Using a suite of novel genomic library preparation techniques and sequencing strategies, we will test the hypothesis that a few genes of large effect are involved in shaping divergent migratory behaviours. Newly developed assays will test for methylation (i.e. turning genes off and on) involvement in migratory behaviour, while selection on the mitochondrial genome will be linked to mitochondrial respiration rates to collectively test the ‘migration-adapted mitochondrion' hypothesis. Using comparative genomics and meta-analyses we will test for a common genomic architecture to migratory behaviour. Finally, the long-term vision of my DG is to develop an empirically-based framework that infers the demographic impact of changing environments; this will be achieved by temporal modelling of migratory habitat and quantitatively linking shifts in habitat to inferred changes in effective population size and other demographic parameters. ******Holistically linking genomic, epigenetic, and respiration patterns to divergent migratory behaviour will provide ground-breaking advances in movement ecology and wildlife genetic research. The innovative merger of traditionally disparate data streams can be applied to terrestrial and marine systems, thereby advancing basic research on multiple fronts. There is a direct impact to ungulate conservation and management in determining how hard-wired migratory behaviours are, and assessing the demographic impact of altered migration habitat. I anticipate training 10 HQP (5 grad; 5 undergrad) in cutting-edge genomics, bioinformatics, and modelling techniques. These skills are highly transferrable and in demand in the growing Canadian bio-economy.
迁徙是一种复杂的行为,在整个动物界中独立和重复地进化,在塑造种群动态和生态系统过程中至关重要。然而,主要由于气候变化和其他人为因素,移徙事件已开始消失。这导致迫切需要了解迁徙的内部驱动因素,重点是基因组结构和生理机制。这种评估的目标是评估人口是否能够应对迁徙路线上的人为和环境变化。*迁徙需要大量的适应,已经证明了明确的遗传模式和遗传基础。我的DG项目旨在通过关注一组独特的有蹄类动物(驼鹿、骡鹿和山山羊)来隐藏迁徙的驱动因素,这些动物表现出一系列的迁徙行为。我的计划的可行性体现在已经拥有多年的GPS跟踪数据和冻结的组织。GPS定位数据将用于确定个体迁徙模式(时间、目的地和栖息地选择),这些模式将与基因组和生理变化定量地联系在一起。*使用一套新的基因组文库准备技术和测序策略,我们将检验几个重要基因参与形成不同的迁移行为的假设。新开发的分析方法将测试甲基化(即关闭和打开基因)是否与迁徙行为有关,而对线粒体基因组的选择将与线粒体呼吸速率联系在一起,共同检验“迁徙适应线粒体”假说。利用比较基因组学和荟萃分析,我们将测试迁徙行为的共同基因组结构。最后,我的副秘书长的长期愿景是建立一个以经验为基础的框架,推断环境变化对人口的影响;这将通过对迁徙栖息地的时间建模和将栖息地的变化与推断的有效人口规模和其他人口参数的变化进行定量联系来实现。*将基因组、表观遗传和呼吸模式与不同的迁徙行为整体联系起来,将在运动生态学和野生动物遗传学研究方面取得突破性进展。传统上截然不同的数据流的创新合并可以应用于陆地和海洋系统,从而推动多个战线的基础研究。在确定迁徙行为的根深蒂固程度以及评估迁徙栖息地变化的人口影响方面,对有蹄类动物的保护和管理有直接影响。我预计将在尖端基因组学、生物信息学和建模技术方面培训10名HQP(5名研究生;5名本科生)。在加拿大日益增长的生物经济中,这些技能具有很高的可转移性和需求量。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Shafer, Aaron其他文献
Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis.
- DOI:
10.1002/ijc.24837 - 发表时间:
2010-03-01 - 期刊:
- 影响因子:6.4
- 作者:
Shafer, Aaron;Zhou, Chunxiao;Gehrig, Paola A.;Boggess, John F.;Bae-Jump, Victoria L. - 通讯作者:
Bae-Jump, Victoria L.
Robotic-assisted endometrial cancer staging and radical hysterectomy with the da Vinci® surgical system
- DOI:
10.1016/j.ygyno.2008.07.023 - 发表时间:
2008-11-01 - 期刊:
- 影响因子:4.7
- 作者:
Shafer, Aaron;Boggess, John F. - 通讯作者:
Boggess, John F.
Shafer, Aaron的其他文献
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{{ truncateString('Shafer, Aaron', 18)}}的其他基金
Quantifying the drivers of animal migration
量化动物迁徙的驱动因素
- 批准号:
RGPIN-2017-03934 - 财政年份:2022
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Developing biomarkers for wildlife management
开发用于野生动物管理的生物标记
- 批准号:
566904-2021 - 财政年份:2021
- 资助金额:
$ 2.11万 - 项目类别:
Alliance Grants
Quantifying the drivers of animal migration
量化动物迁徙的驱动因素
- 批准号:
RGPIN-2017-03934 - 财政年份:2021
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Quantifying the drivers of animal migration
量化动物迁徙的驱动因素
- 批准号:
RGPIN-2017-03934 - 财政年份:2020
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Quantifying the drivers of animal migration
量化动物迁徙的驱动因素
- 批准号:
RGPIN-2017-03934 - 财政年份:2019
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Quantifying the drivers of animal migration
量化动物迁徙的驱动因素
- 批准号:
RGPIN-2017-03934 - 财政年份:2017
- 资助金额:
$ 2.11万 - 项目类别:
Discovery Grants Program - Individual
Adaptation genomics: leading conservation and ecological genetics into the post genomics era
适应基因组学:引领保护和生态遗传学进入后基因组时代
- 批准号:
469007-2014 - 财政年份:2015
- 资助金额:
$ 2.11万 - 项目类别:
Banting Postdoctoral Fellowships Tri-council
Adaptation genomics: leading conservation and ecological genetics into the post genomics era
适应基因组学:引领保护和生态遗传学进入后基因组时代
- 批准号:
469007-2014 - 财政年份:2014
- 资助金额:
$ 2.11万 - 项目类别:
Banting Postdoctoral Fellowships Tri-council
Genetic structure and evolutionary history of north american mountain goats (oreamnos americanus)
北美山羊(oreamnos americanus)的遗传结构和进化史
- 批准号:
348745-2007 - 财政年份:2009
- 资助金额:
$ 2.11万 - 项目类别:
Postgraduate Scholarships - Doctoral
Genetic structure and evolutionary history of north american mountain goats (oreamnos americanus)
北美山羊(oreamnos americanus)的遗传结构和进化史
- 批准号:
348745-2007 - 财政年份:2008
- 资助金额:
$ 2.11万 - 项目类别:
Postgraduate Scholarships - Doctoral
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