DNA Nanoscience

DNA纳米科学

• 批准号: 1000228379-2012
• 负责人: Sleiman, Hanadi
• 金额: $ 14.57万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=665400
• 关键词: DNA; Nanoscience

A central challenge in nanoscience is the organization of functional components into deliberately designed patterns, to achieve specific function. Because of its molecular recognition specificity, DNA presents a unique opportunity to address this problem. Our group has used DNA to synthesize 2D- and 3D-structures with deliberate variation of geometry, size and permeability, and we showed that they readily penetrate mammalian cells. In this proposal, we develop these molecules towards applications for the selective release of therapeutics into diseased cells. We also describe the incorporation of transition metals, gold nanoparticles and synthetic polymers, towards applications in nanoelectronics, plasmonics and biological sensing.

纳米科学中的一个中心挑战是将功能组件组织成精心设计的模式，以实现特定的功能。由于其分子识别的特异性，DNA为解决这一问题提供了一个独特的机会。我们的团队已经使用DNA合成了具有故意改变几何形状、大小和渗透性的2D和3D结构，并且我们发现它们很容易穿透哺乳动物细胞。在这项提议中，我们开发这些分子用于选择性地将治疗药物释放到疾病细胞中。我们还描述了过渡金属、金纳米颗粒和合成聚合物在纳米电子学、等离子体和生物传感方面的应用。