DNA Nanoscience

DNA纳米科学

• 批准号: CRC-2019-00149
• 负责人: Sleiman, Hanadi
• 金额: $ 7.29万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=692689
• 关键词: DNA; Nanoscience

A central challenge in nanoscience is the organization of functional components into deliberately designed structures, to achieve specific function. Because of its molecular recognition specificity, DNA presents a unique opportunity to address this problem. This proposal develops this biomolecule towards selective release of therapeutics into cancer cells, focusing on triple negative breast cancer. The proposal also describes the synthesis of DNA-imprinted polymer particles that dramatically increase the level of control and programmability in polymer self-assembly.

纳米科学的一个核心挑战是将功能组件组织成故意设计的结构，以实现特定的功能。由于其分子识别特异性，DNA为解决这一问题提供了独特的机会。该提案开发了这种生物分子，将治疗剂选择性释放到癌细胞中，重点关注三阴性乳腺癌。该提案还描述了DNA印迹聚合物颗粒的合成，其显著提高了聚合物自组装的控制和可编程性水平。