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In-vivo glucoCEST MRI - The future of organ metabolic imaging

In-vivo glucoCEST MRI - The future of organ metabolic imaging
体内 glucoCEST MRI - 器官代谢成像的未来
批准号:
531292-2018
负责人:
Sussman, Dafna
金额:
$1.82万
依托单位:
依托单位国家:
加拿大
项目类别:
Engage Grants Program
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-01-01 至 2019-12-31

项目摘要

项目成果

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中文摘要
翻译
胎儿代谢成像目前还不可用,但它的发展是了解胎儿发育和生理的关键。由于葡萄糖是胎儿能量的主要来源,因此能够对胎儿器官的吸收和利用进行成像,可以揭示有关胎儿器官生长和功能的新信息。在拟议的研究中,行业合作伙伴希望开发一种非侵入性成像技术,通过不同的胎儿器官追踪葡萄糖代谢。这项技术的核心是磁共振成像(MRI),它没有有害的辐射,被认为对母亲和胎儿是安全的。行业合作伙伴已经开始开发这项技术,但目前仍然是一个无法使用的产品。在拟议的合作中,我们 ** 将致力于进一步开发这项技术,以便将其转化为可用的,可销售的成像产品。我们将对目前可用的工业 ** 产品进行分析、计算机模拟、优化和测试,从而提高其在胎儿成像中的能力和实用性。由此产生的改进的和可销售的 ** 产品将解决胎儿成像中的当前技术差距,同时满足对成像代谢过程的非侵入性 ** 手段的日益增长的需求。该项目的成功完成将为西门子带来巨大的价值 **,因为它在技术能力方面推动了胎儿成像的界限,允许新的 ** 技术建立在它的基础上,同时促进了在 ** 加拿大和国际上理解母胎生理学的新科学途径。
英文摘要
Imaging of fetal metabolism is currently unavailable but its development is key to understanding fetal**development and physiology. Since glucose is the primary source of energy for the fetus, being able to image**its uptake and utilization by the fetal organs could reveal new information about fetal organ growth and**function.**In the proposed study, the industry partner would like to develop a non-invasive imaging technique that traces**glucose metabolism by the different fetal organs. The technique pivots on magnetic resonance imaging (MRI),**which has no harmful radiation and is considered safe for the mother and the fetus. The industry partner has**started developing this technique, yet it is currently still an unusable product. In the proposed collaboration we**will work on further developing this technique in order to turn it into a usable, marketable imaging product.**We will carry out analysis, computer simulation, optimization, and testing of the currently available industry**product, thereby improving its capabilities and utility in fetal imaging. The resulting improved and marketable**product will address a current technical gap in fetal imaging whiles satisfying a growing need for non-invasive**means of imaging metabolic processes. The successful completion of this project will bring tremendous value**to Siemens as it pushes the boundaries of fetal imaging in terms of technical capabilities, allowing new**techniques to build on it while facilitating new scientific avenues in understanding maternal-fetal physiology in**Canada and internationally.
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Magnetic Resonance Tools for Fetal Developmental and Metabolic Assessment
  • 批准号:
    RGPIN-2018-04155
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.75万
  • 财政年份:
    2022
  • 负责人:
    Sussman, Dafna
  • 依托单位:
Magnetic Resonance Tools for Fetal Developmental and Metabolic Assessment
  • 批准号:
    RGPIN-2018-04155
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.75万
  • 财政年份:
    2021
  • 负责人:
    Sussman, Dafna
  • 依托单位:
Magnetic Resonance Tools for Fetal Developmental and Metabolic Assessment
  • 批准号:
    RGPIN-2018-04155
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.75万
  • 财政年份:
    2020
  • 负责人:
    Sussman, Dafna
  • 依托单位:
Automatic COVID-19 pregnant patient prognosis algorithm
  • 批准号:
    553722-2020
  • 项目类别:
    Alliance Grants
  • 资助金额:
    $3.64万
  • 财政年份:
    2020
  • 负责人:
    Sussman, Dafna
  • 依托单位:
国内基金
海外基金
基于5.0T超高场MRI的糖尿病肾病葡萄糖代谢的GlucoCEST定量研究
  • 批准号:
    82302141
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2023
  • 负责人:
    邢兆宇
  • 依托单位: