In-vivo glucoCEST MRI - The future of organ metabolic imaging

体内 glucoCEST MRI - 器官代谢成像的未来

• 批准号: 531292-2018
• 负责人: Sussman, Dafna
• 金额: $ 1.82万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=666253
• 关键词: vivo; glucoCEST; MRI; future; organ

Imaging of fetal metabolism is currently unavailable but its development is key to understanding fetal**development and physiology. Since glucose is the primary source of energy for the fetus, being able to image**its uptake and utilization by the fetal organs could reveal new information about fetal organ growth and**function.**In the proposed study, the industry partner would like to develop a non-invasive imaging technique that traces**glucose metabolism by the different fetal organs. The technique pivots on magnetic resonance imaging (MRI),**which has no harmful radiation and is considered safe for the mother and the fetus. The industry partner has**started developing this technique, yet it is currently still an unusable product. In the proposed collaboration we**will work on further developing this technique in order to turn it into a usable, marketable imaging product.**We will carry out analysis, computer simulation, optimization, and testing of the currently available industry**product, thereby improving its capabilities and utility in fetal imaging. The resulting improved and marketable**product will address a current technical gap in fetal imaging whiles satisfying a growing need for non-invasive**means of imaging metabolic processes. The successful completion of this project will bring tremendous value**to Siemens as it pushes the boundaries of fetal imaging in terms of technical capabilities, allowing new**techniques to build on it while facilitating new scientific avenues in understanding maternal-fetal physiology in**Canada and internationally.

胎儿代谢成像目前还不可用，但它的发展是了解胎儿发育和生理的关键。由于葡萄糖是胎儿能量的主要来源，因此能够对胎儿器官的吸收和利用进行成像，可以揭示有关胎儿器官生长和功能的新信息。在拟议的研究中，行业合作伙伴希望开发一种非侵入性成像技术，通过不同的胎儿器官追踪葡萄糖代谢。这项技术的核心是磁共振成像（MRI），它没有有害的辐射，被认为对母亲和胎儿是安全的。行业合作伙伴已经开始开发这项技术，但目前仍然是一个无法使用的产品。在拟议的合作中，我们 ** 将致力于进一步开发这项技术，以便将其转化为可用的，可销售的成像产品。我们将对目前可用的工业 ** 产品进行分析、计算机模拟、优化和测试，从而提高其在胎儿成像中的能力和实用性。由此产生的改进的和可销售的 ** 产品将解决胎儿成像中的当前技术差距，同时满足对成像代谢过程的非侵入性 ** 手段的日益增长的需求。该项目的成功完成将为西门子带来巨大的价值 **，因为它在技术能力方面推动了胎儿成像的界限，允许新的 ** 技术建立在它的基础上，同时促进了在 ** 加拿大和国际上理解母胎生理学的新科学途径。