Nano-Biomolecular Hybrid Materials

纳米生物分子杂化材料

• 批准号: 1000228087-2012
• 负责人: Tang, Tian
• 金额: $ 3.64万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=666508
• 关键词: Nano; Biomolecular; Hybrid; Materials

Integration of novel engineered nanomaterials with biological molecules opens the door to tremendous opportunities for the generation of new materials that can facilitate many important biomedical and nanoengineering applications, examples including the hybridization of nucleic acids with nanomaterials for gene therapy and biosensing applications. Experimental efforts on producing nano-biomolecular hybrid materials have significantly outpaced theoretical attempts to understand the interactions in these materials and the properties of the hybrids, which is necessary in order to provide guidelines for their systematic design in specific applications. The proposed research program aims at filling the current gap between theoretical investigation and practical applications by (1) in the short term, studying representative nano-biomolecular hybrid materials to improve their performance in corresponding applications; and (2) in the long term, developing effective modeling strategies bridging different scales that can be used to characterize these hybrid materials.

新型工程纳米材料与生物分子的整合为新材料的产生带来了巨大的机会，这些新材料可以促进许多重要的生物医学和纳米工程应用，例如核酸与纳米材料的杂交，用于基因治疗和生物传感应用。生产纳米生物分子杂化材料的实验工作已经大大超过了理论上的尝试，以了解这些材料中的相互作用和杂化物的性质，这是必要的，以便为它们在特定应用中的系统设计提供指导方针。拟议的研究计划旨在填补理论研究和实际应用之间的差距，（1）在短期内，研究代表性的纳米生物分子杂化材料，以提高其在相应应用中的性能;（2）从长远来看，开发有效的建模策略，桥接不同的尺度，可用于表征这些杂化材料。