Nanosheet-Biomolecular Hybrid Films Synthesis, Structure, and Controlled Release

纳米片-生物分子杂化薄膜的合成、结构和控释

• 批准号: 2151804
• 负责人: Robert Hurt
• 金额: $ 41.79万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2151804&HistoricalAwards=false
• 关键词: Nanosheet; Biomolecular; Hybrid; Films; Synthesis

Two-dimensional materials are a broad class of atomically thin, sheet-like solids with novel properties. These two-dimensional materials, or “nanosheets”, can be stacked together in various configurations to make macroscopic materials with internal layered structures. Such macroscopic layered materials find use in emerging technologies that include textile barrier layers for personal protective equipment, coatings to stabilize or protect surfaces, drug delivery patches and implantable biomaterials. This project seeks to enhance the functions of these layered materials by incorporating biologically active molecules to make hybrids. A major focus is to measure and predict the rates at which those imbedded biomolecules are released, and become active and functional on the outer surfaces and nearby fluid phases. This controlled release can be used to create long-lifetime antibacterial and antiviral coatings for surfaces, textile layers that release insect repellants, or biomaterials that provide timed delivery of drugs. The research will identify methods for controlling the release rate and thus controlling the active lifetime of these devices by manipulating the methods of synthesis and processing. The research team will also be engaged in activities that motivate and prepare underrepresented groups for studies and careers in engineering and science. The principal investigators will collaborate with societies promoting engineering career choices and advancement for women, Hispanics, and Native Americans and will host a Rhode Island Science Day event featuring tours, demonstrations and hands-on activities for upper elementary and middle school tribal youth in the state to introduce and promote opportunities in science and engineering. This project will create, characterize and apply a new set of hetero-structured layered materials with active biomolecular species intercalated in the van der Waals gaps between stacked two-dimensional nanosheets. These frontier hybrids combine the novel properties of atomically-thin nanosheets with the targeted, chemically specific functions of biomolecules. The project will pursue the hypothesis that molecular release kinetics are governed by internal transport processes involving molecular diffusion through nanochannels. Nanochannel transport phenomena are poorly understood, as are the implications for the timing, location, and direction of molecular release from films or macroscopic layered monoliths. The research plan has three Objectives: (1) to synthesize and characterize a panel of hybrid layered materials; (2) to measure biomolecular release kinetics and elucidate release mechanisms to identify design strategies for control; and (3) to demonstrate multifunctional 2D hybrid devices and characterize their dynamic expression of biochemical surface activity in case studies focused on antibacterial and antiviral function. Scientific outputs from this project will include a suite of new hybrid materials with information on their structures and properties, the first quantitative models for release rate prediction and control, and values of nanochannel diffusion coefficients for a range of molecules obtained by model-based extraction from molecular release rate data. The investigator team will also engage in educational outreach to motivate and prepare students from underrepresented groups for studies and careers in science and engineering.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

二维材料是一类原子级薄的片状固体，具有新颖的性质。 这些二维材料或“纳米片”可以以各种配置堆叠在一起，以制造具有内部分层结构的宏观材料。 这种宏观层状材料可用于新兴技术，包括用于个人防护设备的纺织品屏障层、稳定或保护表面的涂层、药物递送贴片和可植入生物材料。 该项目旨在通过引入生物活性分子来制造杂交体来增强这些分层材料的功能。 一个主要的焦点是测量和预测这些嵌入的生物分子被释放的速率，并在外表面和附近的流体相中变得活跃和功能化。 这种受控释放可用于为表面、释放驱虫剂的纺织品层或提供定时药物递送的生物材料创建长寿命的抗菌和抗病毒涂层。 该研究将确定控制释放速率的方法，从而通过操纵合成和加工方法来控制这些装置的有效寿命。 研究团队还将参与激励和准备代表性不足的群体在工程和科学的研究和职业活动。 主要研究人员将与促进妇女，西班牙裔和美洲原住民的工程职业选择和进步的社会合作，并将举办罗得岛科学日活动，包括图尔斯，示范和实践活动，为上小学和中学的部落青年在该州介绍和促进科学和工程的机会。该项目将创建，表征和应用一组新的异质结构层状材料，其中活性生物分子物种插入堆叠的二维纳米片之间的货车德瓦尔斯间隙中。 这些前沿杂交联合收割机将原子级薄纳米片的新特性与生物分子的靶向化学特异性功能相结合。该项目将追求的假设，分子释放动力学是由内部运输过程涉及分子扩散通过纳米通道。纳米通道传输现象知之甚少，因为是从膜或宏观层状整料的分子释放的时间，位置和方向的影响。该研究计划有三个目标：（1）合成和表征一组混合层状材料;（2）测量生物分子释放动力学并阐明释放机制，以确定控制的设计策略;（3）展示多功能二维混合装置，并在专注于抗菌和抗病毒功能的案例研究中表征其生物化学表面活性的动态表达。 该项目的科学成果将包括一套新的混合材料及其结构和特性的信息，第一个定量模型用于释放速率预测和控制，以及通过基于模型的提取从分子释放速率数据中获得的一系列分子的纳米通道扩散系数值。 研究者团队还将参与教育推广活动，以激励和准备来自代表性不足群体的学生在科学和工程领域的学习和职业生涯。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Effect of bacterial growth stage on the response to two-dimensional nanomaterials

• DOI: 10.1039/d2en00716a
• 发表时间: 2023
• 期刊: Environmental Science: Nano
• 作者: Zachary J. Shepard;Zachary Saleeba;Muchun Liu;R. Hurt;Vinka Oyanedel-Craver